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  2. Sickle cell disease: MedlinePlus Genetics

    medlineplus.gov/genetics/condition/sickle-cell-disease

    Learn about the genetic causes, inheritance, and treatment of sickle cell disease, a group of disorders that affect hemoglobin and red blood cells. Find out the frequency, symptoms, and resources for this condition.

  3. The sickle β-globin mutation renders the sickle gene pleiotropic in nature, with variable phenotypic expression associated with complex genetic and environmental interactions, as well as disease modifiers that are increasingly being recognised.

  4. Sickle cell disease - Wikipedia

    en.m.wikipedia.org/wiki/Sickle_cell_disease

    Sickle cell disease is a group of blood disorders caused by a genetic mutation in the hemoglobin gene. It affects red blood cells, causing them to become rigid and sickle-shaped, leading to pain, anemia, infections, and organ damage.

  5. About Sickle Cell Disease - National Human Genome Research...

    www.genome.gov/Genetic-Disorders/Sickle-Cell-Disease

    Sickle cell disease is a genetic disorder that affects hemoglobin, the protein that carries oxygen in red blood cells. Learn about the inheritance, diagnosis, complications and new treatments of this common blood disorder.

  6. Sickle cell anemia is an inherited disorder of the globin chains that causes hemolysis and chronic organ damage. Sickle cell anemia is the most common form of sickle cell disease (SCD), with a lifelong affliction of hemolytic anemia requiring blood transfusions, pain crises, and organ damage.

  7. Sickle Cell Disease (SCD): Types, Symptoms & Causes - Cleveland...

    my.clevelandclinic.org/health/diseases/12100

    Sickle cell disease (SCD) is a genetic disorder that affects the hemoglobin in red blood cells. Learn about the different types of SCD, how they cause pain, anemia and complications, and how they differ from sickle cell trait.

  8. Sickle Cell Disease - Johns Hopkins Medicine

    www.hopkinsmedicine.org/.../sickle-cell-disease

    Sickle cell disease is an inherited blood disorder that causes abnormal red blood cells and low oxygen levels. Symptoms include anemia, pain crises, infections, and organ damage. Learn about the diagnosis, treatment, and complications of this condition.

  9. Sickle cell anemia - Symptoms & causes - Mayo Clinic

    www.mayoclinic.org/diseases-conditions/sickle-cell-anemia/...

    Sickle cell anemia is a genetic disorder that affects the shape and function of red blood cells. Learn about the symptoms, causes, risk factors, complications and prevention of this condition, and how to seek medical attention for emergencies.

  10. What Is Sickle Cell Trait? | Sickle Cell Disease (SCD) | CDC

    www.cdc.gov/sickle-cell/sickle-cell-trait

    Sickle cell trait (SCT) is a genetic condition that affects red blood cells. People with SCT usually do not have symptoms of sickle cell disease (SCD), but they can pass the trait on to their children and experience some rare complications under certain conditions.

  11. Sickle Cell Disease - Causes and Risk Factors | NHLBI, NIH

    www.nhlbi.nih.gov/health/sickle-cell-disease/causes

    Sickle cell disease is a genetic disorder caused by mutations in hemoglobin genes, leading to a faulty hemoglobin protein, called hemoglobin S. Learn how sickle cell disease is inherited, who is at risk, and how it affects red blood cells and blood flow.