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The cause of biliary atresia in Egyptian infants has been proven to be as a result of aflatoxin induced cholangiopathy acquired prenatally in infants who have glutathione S transferase M1 deficiency. The biliary atresia phenotype caused by congenital aflatoxicosis in GST M1 deficient neonates is named Kotb disease. [5]
The causes of neonatal hepatitis are many. Viruses that have been identified include cytomegalovirus, rubella virus, hepatitis A and B viruses, herpes simplex viruses, coxsackievirus, echovirus, and paramyxovirus. [2] Metabolic and immune disorders can also cause neonatal hepatitis. [2] Giant cell transformation throughout the parenchyma is ...
Neonatal cholestasis can present in newborn infants within the first few months of life. [1] The incidence of neonatal cholestasis is approximately 1 in 2,500 term births. [5] While neonatal cholestasis can present from a number of pathologic causes, 35-40% of neonatal cholestasis cases are caused by biliary atresia. [3]
If the neonatal jaundice is not resolved with simple phototherapy, other causes such as biliary atresia, Progressive familial intrahepatic cholestasis, bile duct paucity, Alagille syndrome, alpha 1-antitrypsin deficiency, and other pediatric liver diseases should be considered. The evaluation for these will include blood work and a variety of ...
The scan is also important to differentiate between neonatal hepatitis and biliary atresia, because an early surgical intervention in form of Kasai portoenterostomy or hepatoportoenterostomy can save the life of the baby as the chance of a successful operation after 3 months seriously decreases. [9]
However, hepatitis B virus is the major cause of neonatal infection. [20] Hepatitis A is a non-enveloped, single-stranded RNA virus that is spread through the fecal-oral route with the main modes of transmission being close personal contact or ingestion of contaminated food or water. During pregnancy, hepatitis A can cause placental abruption ...
Congenital or perinatal infection with the hepatitis viruses, toxoplasma, rubella, cytomegalovirus, and syphilis can cause neonatal hepatitis. [55] Structural abnormalities such as biliary atresia and choledochal cysts can lead to cholestatic liver injury leading to neonatal hepatitis. [ 55 ]
2.1 Congenital. 2.1.1 Atretic causes. ... Intrahepatic bile duct atresia ... T cells recognize biliary epithelial cell antigens causing injury and eventual atresia.