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Causes may include sepsis, pancreatitis, trauma, pneumonia, and aspiration. [1] The underlying mechanism involves diffuse injury to cells which form the barrier of the microscopic air sacs of the lungs , surfactant dysfunction, activation of the immune system , and dysfunction of the body's regulation of blood clotting . [ 5 ]
In medicine, the number needed to harm (NNH) is an epidemiological measure that indicates how many persons on average need to be exposed to a risk factor over a specific period to cause harm in an average of one person who would not otherwise have been harmed.
It is believed that there is always a more direct cause, and usually it is one of many age-related diseases. It is estimated that, as a root cause, the aging process underlies 2/3 of all death in the world (approximately 100,000 people per day in 2007).
IRDS affects about 1% of newborns and is the leading cause of morbidity and mortality in preterm infants. [5] Data have shown the choice of elective caesarean sections to strikingly increase the incidence of respiratory distress in term infants; dating back to 1995, the UK first documented 2,000 annual caesarean section births requiring ...
Epidemiologists emphasize that the "one cause – one effect" understanding is a simplistic mis-belief. [53] Most outcomes, whether disease or death, are caused by a chain or web consisting of many component causes. [54] Causes can be distinguished as necessary, sufficient or probabilistic conditions.
The crude death rate is defined as "the mortality rate from all causes of death for a population," calculated as the "total number of deaths during a given time interval" divided by the "mid-interval population", per 1,000 or 100,000; for instance, the population of the United States was around 290,810,000 in 2003, and in that year, approximately 2,419,900 deaths occurred in total, giving a ...
The biochemical basis for the toxicity of oxygen is the partial reduction of oxygen by one or two electrons to form reactive oxygen species, [56] which are natural by-products of the normal metabolism of oxygen and have important roles in cell signalling. [57] One species produced by the body, the superoxide anion (O −
[2] [3] [4] According to an article published in The Lancet in June 2015, low back pain and major depressive disorder were among the top ten causes of YLDs and were the cause of more health loss than diabetes, chronic obstructive pulmonary disease, and asthma combined. The study based on data from 188 countries, considered to be the largest and ...