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The Ames test is a widely employed method that uses bacteria to test whether a given chemical can cause mutations in the DNA of the test organism. More formally, it is a biological assay to assess the mutagenic potential of chemical compounds. [ 1 ]
Ames made contributions to understanding the mechanisms of mutagenesis and DNA repair. He invented the Ames test, a widely used assay for easily and cheaply evaluating the mutagenicity of compounds. [3] The test revolutionized the field of toxicology and has played a crucial role in identifying numerous environmental and industrial carcinogens.
Ames test procedure. One classical bioassay is the Ames test. A strain of Salmonella that requires histidine to grow is put on two plates with growth medium containing minimal amounts of histidine and some rat liver extract (to mimick liver metabolism). A suspected mutagen is added to one plate. If the plate with the suspected mutagen grows ...
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The S9 fraction has been used in conjunction with the Ames test [4] to assess the mutagenic potential of chemical compounds. [5] Chemical substances sometimes require metabolic activation in order to become mutagenic. Furthermore, the metabolic enzymes of bacteria used in the Ames test differ substantially from those in mammals.
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An article by Bruce Ames in The Proceedings of the National Academy of Sciences in 2018 identified pyrroloquinoline quinone as a "longevity vitamin" not essential for immediate survival, but necessary for long-term health. [14]
Bruce Ames (1946), biologist, inventor of the Ames Test, winner of the National Medal of Science [98] Naomi Amir, pediatric neurologist, established first pediatric neurology clinic in Israel [99] Allen J. Bard, a chemist, Priestley Medal recipient, and an influential pioneer of modern electrochemistry.