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Calcifediol, also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D 3 (abbreviated 25(OH)D 3), [1] is a form of vitamin D produced in the liver by hydroxylation of vitamin D 3 (cholecalciferol) by the enzyme vitamin D 25-hydroxylase.
Units of measurement are either ... 10: 25 Children 1–10 years: 15: 50 Children 11–17 years ... The resulting metabolites, such as 20-hydroxyvitamin D3 and 20,23 ...
24,25-dihydroxyvitamin D 3 is formed from 25-hydroxyvitamin D 3 by the action of CYP24A1 (25-hydroxyvitamin D3-24-hydroxylase). CYP24A1 appears to be "a multicatalytic enzyme catalyzing most, if not all, of the reactions in the C-24/C-23 pathway of 25-OH-D 3 metabolism." [5]
25-Hydroxyvitamin D 1-alpha-hydroxylase (VD 1A hydroxylase) also known as calcidiol 1-monooxygenase [5] or cytochrome p450 27B1 (CYP27B1) or simply 1-alpha-hydroxylase is a cytochrome P450 enzyme that in humans is encoded by the CYP27B1 gene. [6] [7] [8]
The liver is required to transform vitamin D into 25-hydroxyvitamin D. This is an inactive metabolite of vitamin D but is a necessary precursor (building block) to create the active form of vitamin D. [1] The kidneys are responsible for converting 25-hydroxyvitamin D to 1,25-hydroxyvitamin D. This is the active form of vitamin D in the body.
Vitamin D is essential for bone health and immune function, and deficiency is common. Consoider one of these vitamin D supplements if you're not getting enough.
The Institute of Medicine in 2010 recommended a maximum uptake of vitamin D of 4000 IU/d, finding that the dose for lowest observed adverse effect level is 40,000 IU daily for at least 12 weeks, [25] and that there was a single case of toxicity above 10 000 IU after more than seven years of daily intake; this case of toxicity occurred in ...
The normal range for blood concentration of 25-hydroxyvitamin D in adults is 20 to 50 nanograms per milliliter (ng/mL). Blood levels necessary to cause adverse effects in adults are thought to be greater than about 150 ng/mL, leading the Endocrine Society to suggest an upper limit for safety of 100 ng/mL. [1]
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