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Repeated exposures to 1/10 of the LCt 50 did not produce overt systemic toxicity or significant pathology. [7] MSF can also cause severe skin burns and serious eye damage, if contact is made. It is a lachrymator and its vapor causes tears in eyes. [8] [2] Methanesulfonyl fluoride has a pungent odor.
The half-life is short in aqueous solutions (110 min at pH 7, 55 min at pH 7.5, and 35 min at pH 8, all at 25 °C). [2] At 4˚C, pH 8, PMSF is almost completely degraded after 1 day. [ 2 ] Stock solutions are usually made up in anhydrous ethanol , isopropanol , or corn oil and diluted immediately before use.
Sulfuryl fluoride (also spelled sulphuryl fluoride) is an inorganic compound with the formula SO 2 F 2. It is an easily condensed gas and has properties more similar to sulfur hexafluoride than sulfuryl chloride , being resistant to hydrolysis even up to 150 °C. [ 3 ]
Methanesulfonyl chloride is mainly used to give methanesulfonates by its reaction with alcohols in the presence of a non-nucleophilic base. [8] In contrast to the formation of toluenesulfonates from alcohols and p-toluenesulfonyl chloride in the presence of pyridine, the formation of methanesulfonates is believed to proceed via a mechanism wherein methanesulfonyl chloride first undergoes an ...
The LD 50 of MSM is greater than 17.5 grams per kilogram of body weight. [16] Extensive research in animal models indicates MSM has a very low toxicity when administered both orally and topically. [17] [18] [19] MSM is considered 'Possibly Safe' at therapeutic doses. [13] [20]
Related to mesylate is the mesyl (Ms) or methanesulfonyl (CH 3 SO 2) functional group. The shortened term itself was coined by Helferich et al. in 1938 similarly to tosyl adopted earlier. [ 4 ] Methanesulfonyl chloride is often referred to as mesyl chloride.
Methanesulfonyl azide melts at 18 °C and decomposes from 120 °C. [1] Like many other azides, it is explosive. [3] At low temperature, methanesulfonyl azide crystallizes in the triclinic crystal system in the space group P1 with the lattice parameters a = 5.6240 Å; b = 5.9498 Å, c = 7.6329 Å, α = 72.216°, β = 70.897°, and γ = 88.601°, and two molecules per unit cell.
57 °C (135 °F; 330 K) [1] at 2 mmHg Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).