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The PICO process (or framework) is a mnemonic used in evidence-based practice (and specifically evidence-based medicine) to frame and answer a clinical or health care related question, [1] though it is also argued that PICO "can be used universally for every scientific endeavour in any discipline with all study designs". [2]
Muriel Skeet, a British nurse, was an early advocate for the development of the evidence base for health care. She produced studies and surveys including Waiting in Outpatients [2] (1965), which received widespread publicity and resulted in the introduction of appointment systems, and Marriage and Nursing [3] (with Gertrude Ramsden, 1967 ...
Misoprostol is approved for medical abortion regimens when administered at the office, but clinicians often give abortion patients the drug to be taken at home. [ 15 ] Modafinil is a central nervous system (CNS) stimulant medication used to treat sleepiness due to narcolepsy , shift work sleep disorder , and obstructive sleep apnea .
The structure-activity relationship of the drug class has been explored to a reasonable extent. The optimal substitution pattern is fairly tightly defined (i.e. N,N-diethyl on the amine nitrogen, 4-ethoxy on the benzyl ring and 5-nitro on the benzimidazole ring), but even derivatives incorporating only some of these features are still potent opioids.
The answer to a research question will help address a research problem or question. [5] Specifying a research question, "the central issue to be resolved by a formal dissertation, thesis, or research project," [6] is typically one of the first steps an investigator takes when undertaking research.
These are lists of investigational drugs: List of investigational analgesics; List of investigational antidepressants; List of investigational antipsychotics; List of investigational anxiolytics; List of investigational attention deficit hyperactivity disorder drugs; List of investigational autism and pervasive developmental disorder drugs
Bayer Healthcare: solid tumors that have a neurotrophic receptor tyrosine kinase (NTRK) gene fusion Larotrectinib [1] Bayer Healthcare: solid tumors that have a neurotrophic receptor tyrosine kinase (NTRK) gene fusion Amifampridine [1] Catalyst Pharmaceuticals: Lambert-Eaton myasthenic syndrome: Pembrolizumab [1] Merck Sharp & Dohme: Merkel ...
Systematic reviews and meta-analyses of clinical research using low doses of certain central nervous system stimulants found that these drugs may enhance cognition in healthy people. [ 13 ] [ 14 ] [ 15 ] In particular, the classes of stimulants that demonstrate possible cognition-enhancing effects in humans have evidence in vitro as direct ...