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The CD nomenclature was proposed and established in the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA), held in Paris in 1982. [4] [5] This system was intended for the classification of the many monoclonal antibodies (mAbs) generated by different laboratories around the world against epitopes on the surface molecules of leukocytes (white blood cells).
Neuropilin-1 (NP-1), NRP1 or BDCA-4, has a wide range of functions. On neurons , it is a receptor for axon growth guidance class-3 semaphorins SEMA3A and plexin-1, on endothelial and some tumor cells it is a VEGF 165 receptor, and on plasmacytoid dendritic cells it has a similar role to CD303 but does not decrease interferon production upon ...
12503 Ensembl ENSG00000198821 ENSMUSG00000005763 UniProt P20963 Q3UU54 P24161 RefSeq (mRNA) NM_000734 NM_198053 NM_001378515 NM_001378516 NM_001113391 NM_001113392 NM_001113393 NM_001113394 NM_031162 RefSeq (protein) NP_000725 NP_932170 NP_001365444 NP_001365445 NP_112439.1 NP_001106862.1 NP_001106862 NP_001106863 NP_001106864 NP_112439 Location (UCSC) Chr 1: 167.43 – 167.52 Mb Chr 1: 165.62 ...
CD4 interacts with the β 2-domain of MHC class II molecules through its D 1 domain. T cells displaying CD4 molecules (and not CD8) on their surface, therefore, are specific for antigens presented by MHC II and not by MHC class I (they are MHC class II-restricted). MHC class I contains Beta-2 microglobulin. [citation needed]
CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells.CD1 glycoproteins are structurally related to the class I MHC molecules, however, in contrast to MHC class 1 proteins, they present lipids, glycolipids and small molecules antigens, from both endogenous and pathogenic proteins, to T cells and activate an immune ...
[5] [6] In humans, CD19 is expressed in all B lineage cells. [ 7 ] [ 8 ] Contrary to some early doubts, human plasma cells do express CD19. [ 9 ] [ 10 ] CD19 plays two major roles in human B cells : on the one hand, it acts as an adaptor protein to recruit cytoplasmic signaling proteins to the membrane; on the other, it works within the CD19 ...
These are not the only molecules that can transverse the blood–brain barrier; glucose, oxygen and carbon dioxide are not lipid-soluble but are actively transported across the barrier, to support the normal cellular function of the brain. [3] The fact that molecules have to fully transverse the endothelial cells makes them a perfect barricade ...
The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain, spinal cord and retina.The CNS is so named because the brain integrates the received information and coordinates and influences the activity of all parts of the bodies of bilaterally symmetric and triploblastic animals—that is, all multicellular animals except sponges and diploblasts.