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Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin, the latter being involved with calcium homeostasis. It arises once preprocalcitonin is cleaved by endopeptidase . [ 1 ] It was first identified by Leonard J. Deftos and Bernard A. Roos in the 1970s. [ 2 ]
So, for example, digoxin has a half-life (or t 1 / 2 ) of 24–36 h; this means that a change in the dose will take the best part of a week to take full effect. For this reason, drugs with a long half-life (e.g., amiodarone , elimination t 1 / 2 of about 58 days) are usually started with a loading dose to achieve their desired ...
Download as PDF; Printable version; In other projects ... Blood test results should always be interpreted using the reference range provided by the laboratory that ...
Instead, the half-life is defined in terms of probability: "Half-life is the time required for exactly half of the entities to decay on average". In other words, the probability of a radioactive atom decaying within its half-life is 50%. [2] For example, the accompanying image is a simulation of many identical atoms undergoing radioactive decay.
Alternatively, since the radioactive decay contributes to the "physical (i.e. radioactive)" half-life, while the metabolic elimination processes determines the "biological" half-life of the radionuclide, the two act as parallel paths for elimination of the radioactivity, the effective half-life could also be represented by the formula: [1] [2]
3667 16367 Ensembl ENSG00000169047 ENSMUSG00000055980 UniProt P35568 P35569 RefSeq (mRNA) NM_005544 NM_010570 RefSeq (protein) NP_005535 NP_034700 Location (UCSC) Chr 2: 226.73 – 226.8 Mb Chr 1: 82.21 – 82.27 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Insulin receptor substrate 1 (IRS-1) is a signaling adapter protein that in humans is encoded by the IRS1 gene. It is a 180 ...
The same review found the sensitivity of the test to be 77% and the specificity to be 79%. The authors suggested that procalcitonin may serve as a helpful diagnostic marker for sepsis, but cautioned that its level alone does not definitively make the diagnosis. [45]
The [A] at which E is 50% of E max is termed the half maximal effective concentration and is abbreviated EC 50, or rarely [A] 50. The term "potency" refers to the EC 50 value. The lower the EC 50 , the less the concentration of a drug is required to produce 50% of maximum effect and the higher the potency.