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Tetrahydrocannabinolic acid (THCA, 2-COOH-THC; conjugate base tetrahydrocannabinolate) is a precursor of tetrahydrocannabinol (THC), an active component of cannabis. [1]THCA is found in variable quantities in fresh, undried cannabis, but is progressively decarboxylated to THC with drying, and especially under intense heating such as when cannabis is smoked or cooked into cannabis edibles.
Consequently, a high-fat meal increases levels of 11-hydroxy-THC by only 25% and most of the increase in bioavailability is due to increased levels of THC. [32] The bioavailability of THC when smoking or inhaling is approximately 25%, with a range of 2% to 56% (although most commonly between 10 and 35%).
However, cannabis does not naturally contain significant amounts of THC. Instead, tetrahydrocannabinolic acid (THCA) is found naturally in raw and live cannabis and is non-intoxicating. Over time, THCA slowly converts to THC through a process of decarboxylation over the course of roughly a year, but can be sped up with exposure to high ...
Because the law limited only Δ 9-THC levels, many other cannabinoids are generally considered legal to sell and are widely available in stores and online, including Δ 8-THC, Δ 10-THC, HHC, and THCP, [68] [69] but have not had the same in-depth research that the Δ 9 isomer has on the human body; carrying potential risks in the short- or long ...
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Just like blood testing, saliva testing detects the presence of parent drugs and not their inactive metabolites. This results in a shorter window of detection for cannabis by saliva testing. [23] Delta 9 THC is the parent compound. If a saliva sample is tested in a lab, the detection level can be as low as 0.5 ng/mL (up to 72 hours after intake ...
Therefore, THCA synthase is considered to be a key enzyme controlling cannabis psychoactivity. [1] Polymorphisms of THCA synthase result in varying levels of THC in Cannabis plants, resulting in "drug-type" and "fiber-type" C. sativa varieties. [2] [3]
Then, THC levels drop rapidly to less than 2 nanograms per milliliter of blood after about four hour. It takes around eight hours to reach similarly low concentrations of THC after taking an edible.