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Colorized scanning electron micrograph of a human neutrophil ingesting MRSA. Methicillin-resistant Staphylococcus aureus (MRSA) is a group of gram-positive bacteria that are genetically distinct from other strains of Staphylococcus aureus. MRSA is responsible for several difficult-to-treat infections in humans.
Problematically, methicillin-resistant Staphylococcus aureus (MRSA) has become a major cause of hospital-acquired infections. MRSA has also been recognized with increasing frequency in community-acquired infections. [7] The symptoms of a staphylococcal infection include a collection of pus, such as a boil or furuncle, or abscess.
Resistance is conferred by the mecA gene, which codes for an altered penicillin-binding protein (PBP2a or PBP2') that has a lower affinity for binding β-lactams (penicillins, cephalosporins, and carbapenems). This allows for resistance to all β-lactam antibiotics, and obviates their clinical use during MRSA infections.
ST8:USA300 is a strain of community-associated methicillin-resistant Staphylococcus aureus that has emerged as a particularly antibiotic resistant epidemic that is responsible for rapidly progressive, fatal diseases including necrotizing pneumonia, severe sepsis and necrotizing fasciitis. [1]
Resistance to methicillin is conferred by activation of a new bacterial penicillin binding protein (PBP) mecA gene. This encodes protein PBP2a. This encodes protein PBP2a. PBP2a works in a similar manner to other PBPs, but it binds β-lactams with very low affinity, meaning they do not compete efficiently with the natural substrate of the ...
Meca or MECA may refer to: Biology. mecA, responsible for methicillin resistance in MRSA; Meca, a snout moth genus in the subfamily Pyralinae; Places Meca ...
Symptoms include red or purple or black skin, swelling, severe pain, fever, and vomiting. [3] The most commonly affected areas are the limbs and perineum. [2] Bacterial infection is by far the most common cause of necrotizing fasciitis. Despite being called a "flesh-eating disease", bacteria do not eat human tissue.
Dukes' disease, named after Clement Dukes (1845–1925), [1] [2] also known as fourth disease, [3] Filatov-Dukes' disease (after Nil Filatov), [4] Staphylococcal Scalded Skin Syndrome (SSSS), [5] or Ritter's disease [6] is an exanthem (rash-causing) illness primarily affecting children and historically described as a distinct bacterial infection, though its existence as a separate disease ...