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Pheochromocytoma is a rare tumor of the adrenal medulla ... intravenous bolus of phentolamine, ... Treatment with 177 Lu-DOTATATE first demonstrated success in ...
The primary application for phentolamine is for the control of hypertensive emergencies, most notably due to pheochromocytoma. [5]It also has usefulness in the treatment of cocaine-induced cardiovascular complications, where one would generally avoid β-blockers (e.g. metoprolol), as they can cause unopposed α-adrenergic mediated coronary vasoconstriction, worsening myocardial ischemia and ...
Its only current clinical use is in preparing patients with pheochromocytoma for surgery; its irreversible antagonism and the resultant depression in the maximum of the agonist dose-response curve are desirable in a situation where surgical manipulation of the tumour may release a large bolus of pressor amine into the circulation. Typically ...
In patients with this disease, a catecholamine-secreting tumor is formed, and causes excess CNS stimulation, such as excess sweating and tachycardia. Nonselective alpha blockers, such as phenoxybenzamine or phentolamine, can be used to mitigate this disease. Pheochromocytoma is a disease in which a catecholamine secreting tumor develops.
FDA-approved uses of these drugs include treating conditions like benign prostatic hyperplasia, hypertension, pheochromocytoma, extravasation management, and reversal of local anesthesia. [1] Common examples of alpha 1 blockers are Tamsulosin, Prazosin, Phentolamine, and Phenoxybenzamine. [1]
Multiple endocrine neoplasia type 2 (also known as "Pheochromocytoma (codons 630 and 634) and amyloid producing medullary thyroid carcinoma", [1] "PTC syndrome," [1] and "Sipple syndrome" [1]) is a group of medical disorders associated with tumors of the endocrine system. The tumors may be benign or malignant .
Treatment of PC12 cells with dexamethasone differentiates them into chromaffin-like cells. Using patch clamp recording and amperometry , there was a significant increase in quantal size, excitability and coupling between calcium channels and vesicle release sites, increasing from ~2x10 −19 to ~6.5x10 −19 moles.
Paroxysmal hypertension, pheochromocytoma-induced sweating [24] Dibenzyline [25] Phentolamine: Non-selective alpha blocker: Reversal agent for unnecessary prolonged local analgesia [26] Regitine [27] Prazosin: Selective alpha-1 blocker: Hypertension, benign prostatic hyperplasia, PTSD associated nightmares and Raynaud phenomenon [28] APO-PRAZO ...