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  2. Myosin light-chain kinase - Wikipedia

    en.wikipedia.org/wiki/Myosin_light-chain_kinase

    Binding of calcium ion to this domain increases the affinity of MYLK binding to myosin light chain. This myosin binding domain is located at the C-Terminus end of the kinase. On the other side of the kinase at the N-Terminus end, sits the actin-binding domain, which allows MYLK to form interactions with actin filaments, keeping it in place. [4] [5]

  3. Protein kinase domain - Wikipedia

    en.wikipedia.org/wiki/Protein_kinase_domain

    The protein kinase domain is a structurally conserved protein domain containing the catalytic function of protein kinases. [2] [3] [4] Protein kinases are a group of enzymes that move a phosphate group onto proteins, in a process called phosphorylation. This functions as an on/off switch for many cellular processes, including metabolism ...

  4. MYL9 - Wikipedia

    en.wikipedia.org/wiki/MYL9

    Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase.

  5. Myosin-heavy-chain kinase - Wikipedia

    en.wikipedia.org/wiki/Myosin-heavy-chain_kinase

    In enzymology, a myosin-heavy-chain kinase (EC 2.7.11.7) is an enzyme that catalyzes the chemical reaction. ATP + [myosin heavy-chain] ADP + [myosin heavy-chain] phosphate Thus, the two substrates of this enzyme are ATP and myosin heavy-chain, whereas its two products are ADP and myosin heavy-chain phosphate.

  6. Myosin - Wikipedia

    en.wikipedia.org/wiki/Myosin

    Myosin X is an unconventional myosin motor, which is functional as a dimer. The dimerization of myosin X is thought to be antiparallel. [53] This behavior has not been observed in other myosins. In mammalian cells, the motor is found to localize to filopodia. Myosin X walks towards the barbed ends of filaments.

  7. Myosin light chain - Wikipedia

    en.wikipedia.org/wiki/Myosin_light_chain

    Myosin light chain kinase (MLCK) inhibitors are one of the few peptides that can cross the plasma membrane relatively quickly. Under stressful conditions, MLCK's in the human body promotes increased permeability of microvessels. It is thought that MLCK phosphorylates endothelial myosin, leading to cell contraction.

  8. Rho-associated protein kinase - Wikipedia

    en.wikipedia.org/wiki/Rho-associated_protein_kinase

    Protein kinase C and Rho-associated protein kinase are involved in regulating calcium ion intake; these calcium ions, in turn stimulate a myosin light chain kinase, forcing a contraction. [5] Rho-associated protein kinase are serine or threonine kinases that determine the calcium sensitivity in smooth muscle cells.

  9. Stress fiber - Wikipedia

    en.wikipedia.org/wiki/Stress_fiber

    ROCK is a kinase that acts to phosphorylate MLCP (myosin-light-chain phosphatase), as well as the NMMII light chain, which inactivates MLCP and activates myosin. [6] This will lead to the accumulation of activated myosin motor proteins, which bind the actin filaments that were polymerized by mDia, to create stress fibers.

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