Search results
Results from the WOW.Com Content Network
Pavlov introduced the ideas of strength of excitation and inhibition, as well as mobility, irradiation, and generalization in the central nervous system. [ 3 ] [ 4 ] [ 5 ] Strength of excitation was considered to be the most important of the nervous system properties by Pavlov because we are often confronted by stimuli in the environment that ...
Histamine H 3 receptors are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where they act as autoreceptors in presynaptic histaminergic neurons and control histamine turnover by feedback inhibition of histamine synthesis and release. [5]
Glycine and its receptor were first suggested to play a role in inhibition of cells in 1965. [8] Two years later, experiments showed that glycine had a hyperpolarizing effect on spinal motor neurons [9] due to increased chloride conductance through the receptor. [10]
Renshaw cells are also the target of the toxin of Clostridium tetani, a Gram positive, spore-forming anaerobic bacterium that lives in the soil, and causes tetanus.When wounds are contaminated with C. tetani, the toxin travels to the spinal cord where it inhibits the release of glycine, an inhibitory neurotransmitter, from Renshaw cells.
Reversible inhibitors occupy the esteratic site for short periods of time (seconds to minutes) and are used to treat of a range of central nervous system diseases. Tetrahydroaminoacridine (THA) and donepezil are FDA-approved to improve cognitive function in Alzheimer's disease.
The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord.The CNS is so named because the brain integrates the received information and coordinates and influences the activity of all parts of the bodies of bilaterally symmetric and triploblastic animals—that is, all multicellular animals except sponges and diploblasts.
Excitotoxicity can occur from substances produced within the body (endogenous excitotoxins).Glutamate is a prime example of an excitotoxin in the brain, and it is also the major excitatory neurotransmitter in the central nervous system of mammals. [14]
Acetylcholine Acetylcholinesterase Acetylcholinesterase inhibition. Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, [1] inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter acetylcholine into choline and acetate, [2] thereby increasing both the level and duration of action of acetylcholine in the central nervous system, autonomic ...