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The pancreatic duct or duct of Wirsung (also, the major pancreatic duct due to the existence of an accessory pancreatic duct) is a duct joining the pancreas to the common bile duct. This supplies it with pancreatic juice from the exocrine pancreas , which aids in digestion .
The ductal pancreas network originates from the central pancreatic duct—this main duct with the bile duct opens into the duodenum. The ductal cells of the main pancreatic duct are bound by connective tissue and produce a columnar epithelium. [3] Interlobular ducts originate from the main pancreatic duct and connect the various pancreatic lobes.
These lobular ducts finally converge to form the main pancreatic duct. [1] These pancreatic ducts can act as a response mechanism when injury occurs and to avoid disruptions in the pancreatic lumen. [3] This keeps the ionic content in check while keeping it open for flow to occur. Mutations that can occur because of blockage/ accumulation in ...
In about 10% of adults, an accessory pancreatic duct may be present if the main duct of the dorsal bud of the pancreas does not regress; this duct opens into the minor duodenal papilla. [11] If the two buds themselves, each having a duct, do not fuse, a pancreas may exist with two separate ducts, a condition known as a pancreas divisum.
The double duct sign is a radiological finding characterized by the simultaneous dilation of the common bile duct and the main pancreatic duct.This sign is significant because it often indicates an obstruction in the distal bile duct and pancreatic duct, frequently caused by serious underlying pathologies such as pancreatic carcinoma or periampullary tumors. [1]
The isthmus (also called the central pancreas) is the region of the gland that runs anterior to the superior mesenteric artery; by convention, it divides the right and left sides of the pancreas. [2] The ventral pancreatic bud forms the pancreatic head and uncinate process. The glands continue to develop but the duct systems anastomose.
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The major duodenal papilla (papilla of Vater) is a rounded projection in the duodenum into which the common bile duct and pancreatic duct drain. The major duodenal papilla is, in most people, the primary mechanism for the secretion of bile and other enzymes that facilitate digestion.