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Furthermore, numerous clinical trials have shown gluconate chelated stannous fluoride toothpastes possess superior protection against dental erosion and dentine hypersensitivity compared to other fluoride-containing and fluoride-free toothpastes. [32] Much of the toothpaste sold in the United States has 1,000 to 1,100 parts per million fluoride.
Topical fluorides are fluoride-containing drugs indicated in prevention and treatment of dental caries, particularly in children's primary dentitions. [1] The dental-protecting property of topical fluoride can be attributed to multiple mechanisms of action, including the promotion of remineralization of decalcified enamel, the inhibition of the cariogenic microbial metabolism in dental plaque ...
Fluorine is often added to drug molecules during drug design, as even a single atom can greatly change the chemical properties of the molecule in desirable ways. Because of the considerable stability of the carbon–fluorine bond , many drugs are fluorinated to delay their metabolism , which is the chemical process in which the drugs are turned ...
Fluoride toothpaste. Fluoride is a mineral that prevents or reverses tooth decay and stimulates new bone formation, according to the National Institutes of Health.
Stannous fluoride is an alternative to sodium fluoride for the prevention of cavities (tooth decay).It was first released commercially in 1956, in Crest toothpaste. It was discovered and developed by Joseph Muhler and William Nebergall.
Fluoride protects tooth enamel from attack by bacteria that cause dental caries (cavities). Although developed by a chemist at Procter and Gamble , its use in toothpaste ( Colgate toothpaste and Ultra Brite ) was patented by Colgate-Palmolive , as Procter and Gamble was engaged in the marketing of Crest toothpaste (containing stannous fluoride ...
Fluoride is commonly found in toothpastes. Fluoride can be delivered to many parts of the oral cavity during brushing, including the tooth surface, saliva, soft tissues and remaining plaque biofilm. [4] Some remineralization methods may work for "white spot lesions" but not necessarily "intact tooth surfaces". [19]
Studies of more than 5,700 children conducted before fluoride-fortified toothpaste became widely available in the mid-1970s found that adding fluoride to water systems reduced the number of ...