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Capsule fill weight is a critical attribute in encapsulation and various real-time fill weight monitoring techniques such as near-infrared spectroscopy (NIR) and vibrational spectroscopy are used, as well as in-line weight checks, to ensure product quality. [7]
Several common factors can include: assurance of patient safety, assurance of the efficacy of the drug through the intended shelf life, [1] uniformity of the drug through different production lots, thorough documentation of all materials and processes, control of possible migration of packaging components into the drug, control of degradation ...
Lubricants prevent ingredients from clumping together and from sticking to the tablet punches or capsule filling machine. Lubricants also ensure that tablet formation and ejection can occur with low friction between the solid and die wall, as well as between granules, which helps in uniform filling of the die.
The dies contain recesses in the desired size and shape, which cut out the ribbons into a two-dimensional shape, and form a seal around the outside. At the same time a pump delivers a precise dose of fill material through a nozzle incorporated into a filling wedge whose tip sits between the two ribbons in between two die pockets at the point of ...
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Coni-Snap capsules are distributed in multiple sizes and colors. [8] The body section of the Coni-Snap design has a tapered rim to facilitate encapsulation on high-speed capsule-filling machines. It has a dual snap-ring locking system that provides an initial attachment prior to capsule filling and a final closure of the filled capsule.
A combination drug (or fixed-dose combination; FDC) is a product that contains more than one active ingredient (e.g., one tablet, one capsule, or one syrup with multiple drugs). In naturopathy , dosages can take the form of decoctions and herbal teas , in addition to the more conventional methods mentioned above.
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