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[2] [3] It is primarily used for the treatment of plaque psoriasis and acne. [4] Tazarotene is also used as a therapeutic for photoaged and photodamaged skin. [4] It is a member of the acetylenic class of retinoids. [4] Tazarotene was approved for medical use in 1997 [5] and is available as a generic medication. [6] [7]
Benzyl bromide is used in organic synthesis for the introduction of the benzyl groups when the less expensive benzyl chloride is insufficiently reactive. [6] [7] Benzylations are often achieved in the presence of catalytic amounts of sodium iodide, which generates the more reactive benzyl iodide in situ. [3]
[17] [18] The tracer then distributes in the body and specifically binds to its target αvβ6-integrin, while an excess is excreted via the kidneys and the urine. As a result, 68 Ga-Trivehexin and, therefore, the positron-emitting radionuclide 68 Ga, is preferably accumulated by αvβ6-integrin abundant tissues (for example, tumor tissue).
In a rat experiment with radiolabeled [14C]-benzotrichloride a single 40 mg/kg body weight dose was administered. The absorption half-life of BTC from the gastrointestinal tract was determined to be 3 hours. The concentration in the blood peaked at 4 h reaching 6.5 ppm, this decreased to 2.6 ppm after 24 h.
The 2,4,6- isomer is easily produced by deprotonation of 1,3,5-trichlorobenzene followed by reaction with carbon dioxide. [1] Its conversion to 2,4,6-trichlorobenzoyl chloride makes it a key intermediate in the Yamaguchi esterification protocol.
All three have been synthesized by various routes: 1-Bromo-2-chlorobenzene: from 2-chloroaniline, via diazotization followed by a Sandmeyer reaction [1]; 1-Bromo-3-chlorobenzene: by (3-chlorophenyl)trimethylgermanium by electrophilic substitution [2] [better source needed]
Benzyl chloroformate, also known as benzyl chlorocarbonate or Z-chloride, is the benzyl ester of chloroformic acid. It can be also described as the chloride of the benzyloxycarbonyl (Cbz or Z) group. In its pure form it is a water-sensitive oily colorless liquid, although impure samples usually appear yellow.
4-Bromobenzaldehyde [3] [4] Structure Molecular formula: C 7 H 5 BrO (BrC 6 H 4 COH) Molar mass: 185.020 g/mol Appearance colorless liquid colorless liquid white solid CAS number [6630-33-7] [3132-99-8] [1122-91-4] Properties Density and phase: 1.585 g/ml, liquid 1.587 g/ml, liquid solid Solubility in water: practically insoluble Melting point ...