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Haemophilia B, also spelled hemophilia B, is a blood clotting disorder causing easy bruising and bleeding due to an inherited mutation of the gene for factor IX, and resulting in a deficiency of factor IX. It is less common than factor VIII deficiency (haemophilia A). [3] Haemophilia B was first recognized as a distinct disease entity in 1952. [4]
Haemophilia can be diagnosed before, during or after birth if there is a family history of the condition. Several options are available to parents. If there is no family history of haemophilia, it is usually only diagnosed when a child begins to walk or crawl. Affected children may experience joint bleeds or easy bruising. [34]
Disease states such as insufficient or malfunctioning platelets, other coagulation deficiencies, or vascular disorders, such as venous blockage associated with severe allergies [9] can lead to the formation of purpura which is not to be confused with trauma-related bruising/contusion. [10]
The condition is associated with sailors who weren't eating fruit and vegetables — but it's more common than you'd think. ... joint pain, easy bruising, dry skin and poor wound healing ...
Symptoms of Peyronie’s Disease. The most apparent symptom of Peyronie’s disease is a deformity of the aroused privates, which can be a new curvature of the privates or a focal loss of aroused ...
Various types of hemophilia and von Willebrand disease are the major genetic disorders associated with coagulopathy. Rare examples are Bernard–Soulier syndrome, Wiskott–Aldrich syndrome and Glanzmann's thrombasthenia. Gene therapy treatments may be a solution as they involve in the insertion of normal genes to replace defective genes ...
Some medical treatments are associated with amyloid disease, but this is rare. [19] Amyloid-forming proteins aggregate into distinctive fibrillar forms with a beta-sheet structure. [19] [20] The beta-sheet form of amyloid is proteolysis-resistant, meaning it can not be degraded or broken down. [5]
Anemia may lead to fatigue, pale skin, severe bruising, and a fast heart rate. [9] Low platelets are associated with an increased risk of bleeding, bruising, and petechiae, with lower blood counts that impact the ability of the blood to clot. Low white blood cells increase the risk of infections. [9]
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