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[4] [6] Glucosamine is marketed as a supplement to support the structure and function of joints, and the marketing is targeted to people with osteoarthritis. [4] [6] Commonly sold forms of glucosamine are glucosamine sulfate, [4] glucosamine chondroitin, glucosamine hydrochloride, [5] and N-acetylglucosamine.
Glucosamine sulfate may be efficacious in ways that glucosamine hydrochloride is not. [11] The Osteoarthritis Research Society International advises arthritis sufferers to discontinue glucosamine therapy if they notice no benefit within six months [ 12 ] and the National Institute for Clinical Excellence no longer recommends its use. [ 13 ]
It is commonly sold together with glucosamine. [5] A 2015 Cochrane review of clinical trials found that most were of low quality, but that there was some evidence of short-term improvement in pain and few side effects; it does not appear to improve or maintain the health of affected joints. [5]
The effectiveness of glucosamine is controversial. [149] Reviews have found it to be equal to [150] [151] or slightly better than placebo. [152] [153] A difference may exist between glucosamine sulfate and glucosamine hydrochloride, with glucosamine sulfate showing a benefit and glucosamine hydrochloride not. [154]
Cialis has several common side effects, many of which also happen with other drugs used to treat ED, like sildenafil (generic Viagra®), vardenafil , and avanafil (Stendra®).
The most common side effects of diacerein treatment are gastrointestinal symptoms including soft stools and diarrhea. [5] These are generally mild to moderate and occur more frequently in the first 2 weeks, and lessen with continued treatment.
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