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The psychoactive effects of cannabis, known as a "high", are subjective and vary among persons and the method of use. When THC enters the blood stream and reaches the brain, it binds to cannabinoid receptors. The endogenous ligand of these receptors is anandamide, the effects of which THC emulates.
When cannabis is inhaled to relieve pain, blood levels of cannabinoids rise faster than when oral products are used, peaking within three minutes and attaining an analgesic effect in seven minutes. [32] A 2011 review considered cannabis to be generally safe, [33] and it appears safer than opioids in palliative care. [34]
A 2017 review suggests that cannabis has been shown to improve the mood of depression-diagnosed patients. [12] This is indicative of a longitudinal relationship between cannabis reduction and improvements in anxiety and depression. Anxiety and depression have been found to increase susceptibility to marijuana use. [52]
A 2022 study published in the Journal of Psychopharmacology found that participants given oral cannabis (the lab-grade alternative to an edible) showed low blood THC concentration at the height of ...
In Phase III trials, the most common adverse effects were dizziness, drowsiness and disorientation; 12% of subjects stopped taking the drug because of the side effects. [57] Dronabinol (brand names Marinol and Syndros) is a delta-9-THC containing drug for treating HIV/AIDS-induced anorexia and chemotherapy-induced nausea and vomiting. [58]
Then, THC levels drop rapidly to less than 2 nanograms per milliliter of blood after about four hour. It takes around eight hours to reach similarly low concentrations of THC after taking an edible.
Cannabis tea, prepared with attention to the lipophilic quality of THC, which is only slightly water-soluble (2.8 mg per liter), [38] often involving cannabis in a saturated fat. [ 39 ] Tincture of cannabis , sometimes known as green dragon, is an alcoholic cannabis concentrate .
No official studies have been conducted on the effects of synthetic cannabinoids on humans (as is often the case with illegal and potentially toxic compounds); [72] however, user reports and the effects experienced by patients seeking medical care after taking synthetic cannabinoids have been published. Each of the many different synthetic ...