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There is little modern clinical research on Dioscorea villosa, and the one study of a wild yam-containing cream for menopausal symptoms failed to find any value from this therapy. [18] According to the American Cancer Society, there is no evidence to support wild yam or diosgenin being either safe or effective in humans. [19]
Diosgenin, a phytosteroid sapogenin, is the product of hydrolysis by acids, strong bases, or enzymes of saponins, extracted from the tubers of Dioscorea wild yam species, such as the Kokoro. It is also present in smaller amounts in a number of other species.
However, a number have been identified, including kaempferol, diosgenin (found in yam), apigenin (found in chasteberry), [1] [3] naringenin, and syringic acid, among others. [2] In addition, 3,8-dihydrodiligustilide from Ligusticum chuanxiong is a potent progestogen ( EC 50 = 90 nM), whereas riligustilide is a weak progestogen (EC 50 ≈ 81 μM).
Progesterone is used as part of hormone replacement therapy in people who have low progesterone levels, and for other reasons. For purposes of comparison with normal physiological circumstances, luteal phase levels of progesterone are 4 to 30 ng/mL, while follicular phase levels of progesterone are 0.02 to 0.9 ng/mL, menopausal levels are 0.03 to 0.3 ng/mL, and levels of progesterone in men ...
Dioscorea alata – also called ube (/ ˈ uː b ɛ,-b eɪ /), ubi, purple yam, or greater yam, among many other names – is a species of yam (a tuber). The tubers are usually a vivid violet - purple to bright lavender in color (hence the common name), but some range in color from cream to plain white.
Progesterone normalizes blood clotting and vascular tone, zinc and copper levels, cell oxygen levels, and use of fat stores for energy. Progesterone may affect gum health, increasing risk of gingivitis (gum inflammation). [99] Progesterone appears to prevent endometrial cancer (involving the uterine lining) by regulating the effects of estrogen.
Manufacturing: both bioidentical and non-bioidentical hormones are synthesized using the same chemical precursors; diosgenin is extracted from soy or yam plants, converted into progesterone and used as a hormone chemical precursor to create the final product. [13] "Natural" is also used to promote the idea of being unmodified, and containing ...
Dioscorea cayenensis subsp. rotundata, commonly known as the white yam, West African yam, [1] Guinea yam, or white ñame, is a subspecies [2] of yam native to Africa. It is one of the most important cultivated yams. [3] Kokoro is one of its most important cultivars. It is sometimes treated as separate species from Dioscorea cayenensis. [1]
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