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Levothyroxine is a synthetic form of thyroxine (T 4), which is secreted by the thyroid gland. Levothyroxine and thyroxine are chemically identical: natural thyroxine is also in the "levo" chiral form, the difference is only in terminological preference. T 4 is biosynthesized from tyrosine. Approximately 5% of the US population suffers from over ...
Thyroid hormones act on nearly every cell in the body. They act to increase the basal metabolic rate , affect protein synthesis , help regulate long bone growth (synergy with growth hormone ) and neural maturation, and increase the body's sensitivity to catecholamines (such as adrenaline ) by permissiveness . [ 12 ]
Thyroxine, also known as T 4, is a hormone produced by the thyroid gland.It is the primary form of thyroid hormone found in the blood and acts as a prohormone of the more active thyroid hormone, triiodothyronine (T 3). [1]
One protocol is to discontinue levothyroxine, then prescribe liothyronine while the T 4 levels are falling, and finally stop the liothyronine two weeks before the radioactive iodine treatment. [6] Liothyronine may also be used for myxedema coma because of its quicker onset of action when compared to levothyroxine. [7]
Levothyroxine should be used to keep TSH levels within the normal range for that trimester. The first-trimester normal range is below 2.5 mIU/L and the second and third trimesters normal range is below 3.0 mIU/L. [16] [44] Treatment should be guided by total (rather than free) thyroxine or by the free T 4 index.
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The onset of TM requires toxic levels of the thyroxine hormone due to overproduction by the thyroid gland. Documented cases have only been diagnosed in conjunction with patients with hyperthyroidism. While hyperthyroidism is more common in women, the development of TM was more common among men with hyperthyroidism.
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