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4-Dimethylaminopyridine (DMAP) is a derivative of pyridine with the chemical formula (CH 3) 2 NC 5 H 4 N. This white solid is of interest because it is more basic than pyridine , owing to the resonance stabilisation from the NMe 2 substituent.
DMAP may refer to: Digital Media Access Protocol, a family of proprietary protocols by Apple; 4-Dimethylaminopyridine (CH 3) 2 NC 5 H 4 N), a derivative of pyridine; 4-Dimethylaminophenol (C 8 H 11 NO), an aromatic compound containing both phenol and amine functional groups; Data Management Advisory Panel, of the England school census
Add the amine to di-tert-butyl dicarbonate, 4-dimethylaminopyridine (DMAP), and acetonitrile (MeCN) at ambient temperature [15] BOC-protected amines are prepared using the reagent di-tert-butyl-iminodicarboxylate. Upon deprotonation, this reagent affords a doubly BOC-protected source of NH − 2, which can be N-alkylated.
First, the carbonyl of the acid attacks the carbodiimide of EDC, and there is a subsequent proton transfer. The primary amine then attacks the carbonyl carbon of the acid which forms a tetrahedral intermediate before collapsing and discharging the urea byproduct. The desired amide is obtained. [6]
The reactivity of anhydrides can be increased by using a catalytic amount of N,N-dimethylaminopyridine ("DMAP") or even pyridine. [12] First, DMAP (2) attacks the anhydride (1) to form a tetrahedral intermediate, which collapses to eliminate a carboxylate ion to give amide 3. This intermediate amide is more activated towards nucleophilic attack ...
Dimethylallyl pyrophosphate (DMAPP; or alternatively, dimethylallyl diphosphate (DMADP); also isoprenyl pyrophosphate) is an isoprenoid precursor.It is a product of both the mevalonate pathway and the MEP pathway of isoprenoid precursor biosynthesis.
DIPEA is a sterically hindered organic base that is commonly employed as a proton scavenger. Thus, like 2,2,6,6-tetramethylpiperidine and triethylamine, DIPEA is a good base but a poor nucleophile, DIPEA has low solubility in water, which makes it very easily recovered in commercial processes, a combination of properties that makes it a useful organic reagent.
4-Dimethylaminophenol (DMAP) is an aromatic compound containing both phenol and amine functional groups. It has the molecular formula C 8 H 11 NO. Uses