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Zinc fingers often bind to a sequence of DNA known as the GC box. [11] The modular nature of the zinc finger motif allows for a large number of combinations of DNA and RNA sequences to be bound with high degree of affinity and specificity, and is therefore ideally suited for engineering protein that can be targeted to and bind specific DNA ...
Zinc finger Y-chromosomal protein is a protein that in humans is encoded by the ZFY gene of the Y chromosome. [3] [4] This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. [4]
This gene on the X chromosome is structurally similar to a related gene on the Y chromosome ().It encodes a member of the krüppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers.
Zinc-finger nucleases (ZFNs) are artificial restriction enzymes generated by fusing a zinc finger DNA-binding domain to a DNA-cleavage domain. Zinc finger domains can be engineered to target specific desired DNA sequences and this enables zinc-finger nucleases to target unique sequences within complex genomes .
ZXDC is a protein composed of 455 amino acids in humans, with a molecular weight of approximately 49.9 kDa. Near its C-terminus, the protein has two C2H2-type zinc finger domains that are likely to be involved in DNA binding and transcriptional control. A flexible linker region that separates
2735 14632 Ensembl ENSG00000111087 ENSMUSG00000025407 UniProt P08151 P47806 RefSeq (mRNA) NM_001160045 NM_001167609 NM_005269 NM_010296 RefSeq (protein) NP_001153517 NP_001161081 NP_005260 NP_034426 Location (UCSC) Chr 12: 57.46 – 57.47 Mb Chr 10: 127.17 – 127.18 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Zinc finger protein GLI1 also known as glioma-associated oncogene is a ...
1 Zinc fingers. 2 Function. 3 Structure. 4 ... finger domain is a protein structural domain of zinc finger type which ... of the finger domains and of the linker ...
LIM domains are protein structural domains, composed of two contiguous zinc fingers, separated by a two-amino acid residue hydrophobic linker. [1] The domain name is an acronym of the three genes in which it was first identified (LIN-11, Isl-1 and MEC-3). [2]
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