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Aldosterone synthase, also called steroid 18-hydroxylase, corticosterone 18-monooxygenase or P450C18, is a steroid hydroxylase cytochrome P450 enzyme involved in the biosynthesis of the mineralocorticoid aldosterone and other steroids. The enzyme catalyzes sequential hydroxylations of the steroid angular methyl group at C18 after initial 11β ...
Aldosterone is increased at low sodium intakes, but the rate of increase of plasma aldosterone as potassium rises in the serum is not much lower at high sodium intakes than it is at low. Thus, potassium is strongly regulated at all sodium intakes by aldosterone when the supply of potassium is adequate, which it usually is in hunter-gatherer diets.
It spontaneously and reversibly converts to various less polar forms and derivatives, some of which serve as precursors to aldosterone or corticosterone. Specifically, 21-hydroxy-11,18-oxido-4-pregnene-3,20-dione (18-DAL) is hydroxylated to aldosterone in the presence of malate and NADP+ at pH 4.8, indicating that 18-DAL acts as a metabolic ...
Steroid 21-hydroxylase is a protein that in humans is encoded by the CYP21A2 gene.The protein is an enzyme that hydroxylates steroids at the C21 position on the molecule. [10] [11] Naming conventions for enzymes are based on the substrate acted upon and the chemical process performed.
Measuring aldosterone alone is not considered adequate to diagnose primary hyperaldosteronism. Rather, both renin and aldosterone are measured, and a resultant aldosterone-to-renin ratio (ARR) is used for case detection. [20] [21] A high aldosterone-to-renin ratio suggests the presence of primary hyperaldosteronism. The diagnosis is made by ...
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Usage on fa.wikipedia.org اعلام استقلال جمهوری دموکراتیک ویتنام; Usage on fr.wikipedia.org Proclamation de l'indépendance de la république démocratique du Vietnam; Usage on ja.wikipedia.org ベトナム独立宣言; Usage on vi.wikipedia.org Tuyên ngôn độc lập (Việt Nam Dân chủ Cộng hòa)
Lê Viết Quốc (born 1982), [1] or in romanized form Quoc Viet Le, is a Vietnamese-American computer scientist and a machine learning pioneer at Google Brain, which he established with others from Google. He co-invented the doc2vec [2] and seq2seq [3] models in natural language processing.