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The term erectile dysfunction does not encompass other erection-related disorders, such as priapism. Treatment of ED encompasses addressing the underlying causes, lifestyle modification, and addressing psychosocial issues. [4] In many instances, medication-based therapies are used, specifically PDE5 inhibitors like sildenafil. [13]
A 2015 systematic review of 15,521 men in which the subjects were measured by health professionals showed that the average length of an erect human penis is 13.12 cm (5.17 inches) long, while the average circumference of an erect human penis is 11.66 cm (4.59 inches).
Sexual dysfunction is especially common among people who have anxiety disorders. [2] [30] [31] [5] Ordinary anxiety can cause erectile dysfunction in men without psychiatric problems, but clinically diagnosable disorders such as panic disorder commonly cause avoidance of intercourse and premature ejaculation. [32]
A high-fat meal does reduce the C max slightly, but it is insignificant. In fact, food does not alter dapoxetine pharmacokinetics. It can be taken with or without food. [26] Distribution. Dapoxetine is absorbed and distributed rapidly in the body. Greater than 99% of dapoxetine is bound to the plasma protein. The mean steady-state volume is 162 L.
Normal total testosterone levels depend on the man's age but generally range from 240 to 950 ng/dL (nanograms per deciliter) or 8.3–32.9 nmol/L (nanomoles per liter). [11] According to American Urological Association, the diagnosis of low testosterone can be supported when the total testosterone level is below 300 ng/dl. [ 12 ]
After their mid-forties, some men report that they do not always have an erection when they are sexually aroused. [9] Equally, a male erection can occur during sleep (nocturnal penile tumescence) without conscious sexual arousal or due to mechanical stimulation (e.g., rubbing against the bed sheet) alone. A young man—or one with a strong ...
Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
The anonymously-written Boxer Codex (c. 1590s) also has a similar description: . Two holes are fashioned in the round part of the hoop or ring, one on the top and the other on the bottom, through which a small bolt or pin made of the same metal as the ring is inserted and which is then thrust through the man’s member as the base of his foreskin.
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