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The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) produced by the body, but also many medications like beta blockers, beta-2 (β 2) antagonists and alpha-2 (α 2) agonists, which are used to treat high ...
This is a table of neurotransmitter actions in the ANS (autonomic nervous system). It includes the circulatory system , the respiratory system , the visual system , the digestive system , the endocrine system , the urinary system , the reproductive system , and the integumentary system .
The alpha-2 (α 2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the G i heterotrimeric G-protein. It consists of three highly homologous subtypes, including α 2A-, α 2B-, and α 2C-adrenergic. Some species other than humans express a fourth α 2D-adrenergic receptor as well. [1]
152 11553 Ensembl ENSG00000184160 ENSMUSG00000045318 UniProt P18825 Q01337 RefSeq (mRNA) NM_000683 NM_007418 RefSeq (protein) NP_000674 NP_031444 Location (UCSC) Chr 4: 3.77 – 3.77 Mb Chr 5: 35.44 – 35.44 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The alpha-2C adrenergic receptor (α 2C adrenoceptor), also known as ADRA2C, is an alpha-2 adrenergic receptor, and also denotes ...
The binding to these receptors by catecholamines will generally stimulate the sympathetic nervous system, the arm of the autonomic nervous system responsible for the fight-or-flight response. Adrenergic receptor autoantibodies are autoantibodies (antibodies directed against a person's own protein) targeting adrenergic receptors.
Other drugs act by binding to a receptor and mimicking the normal neurotransmitter. Such drugs are called receptor agonists. An example of a receptor agonist is morphine, an opiate that mimics effects of the endogenous neurotransmitter β-endorphin to relieve pain. Other drugs interfere with the deactivation of a neurotransmitter after it has ...
They act by antagonizing the α 2-adrenergic receptor and certain serotonin receptors such as 5-HT 2A and 5-HT 2C, [1] but also 5-HT 3, [1] 5-HT 6, and/or 5-HT 7 in some cases. By blocking α 2 -adrenergic autoreceptors and heteroreceptors , NaSSAs enhance adrenergic and serotonergic neurotransmission in the brain involved in mood regulation ...
Adrenergic receptor, a receptor type for epinephrine and norepinephrine; subtypes include α 1, α 2, β 1, β 2, and β 3 receptors; Adrenergic transporter (norepinephrine transporter), a protein transporting norepinephrine from the synaptic cleft into nerve cells; Regarding pharmaceutical drugs: Adrenergic receptor agonist, a type of drug ...