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Hence, 4-AcO-DMT results in modestly lower psilocin levels than psilocybin even when the drugs are given at equivalent doses with adjustment for differences in molecular weight. [2] Along similar lines, the psilocin concentrations with 4-AcO-DMT 15 minutes after administration were 75 to 90% of those of an equimolar dose of psilocybin. [2]
[1] [3] [4] [5] There have also been earlier instances of such stores, for example in Europe in the 2000s. [6] [7] In addition, magic mushroom products are or have been sold by stores and cafes in other parts of the world. [8] [9] [10] The stores may sell actual hallucinogenic mushrooms such as psilocybin mushrooms and Amanita muscaria mushrooms.
Psilacetin (O-acetylpsilocin; 4-AcO-DMT) – non-selective serotonin receptor agonist and psychedelic hallucinogen – substance-related disorders – Psilera [180] Psilocin (PLZ-1015) – non-selective serotonin receptor agonist and psychedelic hallucinogen – pervasive child development disorders – Pilz Bioscience [ 181 ]
Some synthetic substances like 4-AcO-DMT are thought to be prodrugs that metabolize into psychoactive substances that have been used as entheogens. While synthetic DMT and mescaline are reported to have identical entheogenic qualities as extracted or plant-based sources, the experience may wildly vary due to the lack of numerous psychoactive ...
In rodents, 4-HO-TMT showed no head-twitch response (a behavioral proxy of psychedelic effects), hypolocomotion, or hypothermia, in contrast to psilocin and norpsilocin, but similarly to aeruginascin. [3] A synthetic prodrug of 4-HO-TMT, 4-AcO-TMT, has been developed. [1] [5] It is analogous to psilacetin (4-AcO-DMT), a prodrug of psilocin. [1] [5]
4-Acetoxy-DET is orally active, and dosages of 10–25 mg are common. Effects last 4–6 hours. [2] The free base is also active when smoked in a dose range of 5–20 mg. [1] Smoking 4-acetoxy-DET greatly speeds up the onset; peak effects are experienced within 10 minutes, and are usually over within 1 hour.
4,5-Dihydroxytryptamine (4,5-DHT) is a serotonergic neurotoxin of the tryptamine family. [ 1 ] [ 2 ] It is structurally related to the monoamine neurotransmitter serotonin (5-hydroxytryptamine; 5-HT).
4-acetoxy-MET (4-acetoxy-N-methyl-N-ethyl tryptamine), also known as 4-AcO-MET or metacetin, is a hallucinogenic tryptamine. It is the acetate ester of 4-HO-MET, and a homologue of 4-AcO-DMT. It is a novel compound with very little history of human use. [2] It is sometimes sold as a research chemical by online retailers.