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In regards to drug delivery, coiled-coil domains would help overcome some of the hazards of chemotherapeutic drugs, by keeping them from leaking into healthy tissue as they are transported to their target. Coiled-coil domains can be made to bind to specific proteins or cell surface markers, allowing for more precise targeting in drug delivery. [35]
A new report by the Clean Label Project has found that protein powders may contain something other than muscle-building nutrients: lead and cadmium, both of which are toxic.. The national ...
Coiled-coil research began in 1953 when Dr. Francis Crick first reported on the theory behind the packing formation of α-helices in fibrous proteins at the time, which he proposed to consist of alpha helices composed of heptad repeats, or seven-residue repeats (a-b-c-d-e-f-g), whereby 2 or more alpha helices twist around each other similar to the strands of a rope. [2]
WD Repeat and Coiled-coiled containing protein (WDCP) is a protein which in humans is encoded by the WDCP gene. The function of the protein is not completely understood, but WDCP has been identified in a fusion protein with anaplastic lymphoma kinase found in colorectal cancer . [ 5 ]
654818 Ensembl ENSG00000179256 ENSMUSG00000043298 UniProt A2RU48 Q8BQM7 RefSeq (mRNA) NM_001013698 NM_001039558 RefSeq (protein) NP_001013720 NP_001034647 Location (UCSC) Chr 12: 14.8 – 14.81 Mb Chr 6: 136.81 – 136.81 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Single-pass membrane and coiled-coil domain-containing protein 3 is a protein that is encoded in humans by the SMCO3 ...
The protein has 17 predicted alpha helices sites, a characteristic of coiled-coil proteins, and 1 predicted beta-pleated sheet. The following image shows the predicted regions of alpha helices and beta pleated sheets by two programs STRAP [ 9 ] and Quickphyre: [ 10 ] Note: the consensus secondary structures are shown.
Coiled coil domain containing protein 120 (CCDC120), also known as JM11 protein, is a protein that, in humans, is encoded by the CCDC120 gene. [5] The function of CCDC120 has not been formally identified but structural components, conservation, and interactions can be identified computationally.
Apoptosis signal-regulating kinase 1 (ASK1) also known as mitogen-activated protein kinase 5 (MAP3K5) is a member of MAP kinase family and as such a part of mitogen-activated protein kinase pathway. It activates c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases in a Raf-independent fashion in response to an array of ...