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Additional researched vinca alkaloids include vincaminol, vineridine, and vinburnine. Vinpocetine is a semi-synthetic derivative of vincamine (sometimes described as "a synthetic ethyl ester of apovincamine"). [14] Minor vinca alkaloids include minovincine, methoxyminovincine, minovincinine, vincadifformine, desoxyvincaminol, and vincamajine ...
For example, the CHOP regimen consists of cyclophosphamide, doxorubicin, vincristine and prednisone. Besides chemotherapy, medical oncology (pharmacotherapy for cancer) includes several noncytotoxic classes of therapy, such as hormonal therapy and targeted therapy (biologic therapy). Those agents are described in the relevant articles.
1.08 Vinca alkaloids: Vinblastine: IV: Microtubule assembly inhibitor. Arrests cells in M phase. Hodgkin lymphoma, germ cell tumours, non-small cell lung cancer, bladder cancer and primary immune thrombocytopenia: Neurotoxicity, myelosuppression, myocardial ischaemia (rare) and myocardial infarction (rare). Vincristine: IV: As above.
Vinblastine is a vinca alkaloid [9] [2] [10] and a chemical analogue of vincristine. [11] [12] It binds tubulin, thereby inhibiting the assembly of microtubules. [13]Vinblastine treatment causes M phase specific cell cycle arrest by disrupting microtubule assembly and proper formation of the mitotic spindle and the kinetochore, each of which are necessary for the separation of chromosomes ...
Vinca alkaloids were originally manufactured by extracting them from Catharanthus roseus (Madagascar Periwinkle). [1] Podophyllum spp. Two chemotherapy drugs, etoposide and teniposide, are synthetic chemical compounds similar in chemical structure to the toxin podophyllotoxin which is found in Podophyllum peltatum (May Apple). [1] Taxus brevifolia
Category: Vinca alkaloids. ... Download as PDF; Printable version; In other projects ... additional terms may apply. By using this site, ...
The Vinca alkaloids bind to the β-subunit of tubulin dimers at a distinct region called the Vinca-binding domain. They bind to tubulin rapidly, and this binding is reversible and independent of temperature (between 0 °C and 37 °C). In contrast to colchicine, vinca alkaloids bind to the microtubule directly.
In traditional Chinese medicine, extracts from it have been used against numerous diseases, including diabetes, malaria, and Hodgkin's lymphoma. [22] [13] In the 1950s, vinca alkaloids, including vinblastine and vincristine, were isolated from Catharanthus roseus while screening for anti-diabetic drugs. [23]