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While high levels of genetic diversity were one of the original arguments in favor of neutral theory, the paradox of variation has been one of the strongest arguments against neutral theory. There are a large number of statistical methods for testing whether neutral theory is a good description of evolution (e.g., McDonald-Kreitman test [ 20 ...
The Neutral Theory of Molecular Evolution is an influential monograph written in 1983 by Japanese evolutionary biologist Motoo Kimura.While the neutral theory of molecular evolution existed since his article in 1968, [1] Kimura felt the need to write a monograph with up-to-date information and evidences showing the importance of his theory in evolution.
Neutral mutation has become a part of the neutral theory of molecular evolution, proposed in the 1960s. This theory suggests that neutral mutations are responsible for a large portion of DNA sequence changes in a species. For example, bovine and human insulin, while differing in amino acid sequence are still able to perform the same function ...
[3] [1] The surprisingly large amount of molecular divergence within and between species inspired the neutral theory of molecular evolution in the late 1960s. [4] [5] [6] Neutral theory also provided a theoretical basis for the molecular clock, although this is not needed for the clock's validity.
Neutral evolution can therefore be visualised as a population diffusing from one set of sequence nodes, through the neutral network, to another cluster of sequence nodes. Since the majority of evolution is thought to be neutral, [ 14 ] [ 15 ] a large proportion of gene change is the movement though expansive neutral networks.
According to Ohta, however, the nearly neutral theory largely fell out of favor in the late 1980s, because of the mathematically simpler neutral theory for the widespread molecular systematics research that flourished after the advent of rapid DNA sequencing. As more detailed systematics studies started to compare the evolution of genome ...
According to Axe, the research he provides with his book disproves Darwin's theory of evolution, revealing "a gaping hole has been at its center from the beginning." Click through 10 books that ...
If the ratios are the same, then Neutral theory of molecular evolution is true for that loci, and evolution is proceeding primarily through genetic drift. If there are more nonsynonymous substitutions between species than within a species, positive natural selection is occurring on beneficial alleles and natural selection is taking place. [ 3 ]
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