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The primary antidote to brodifacoum poisoning is immediate administration of vitamin K 1 (dosage for humans: initially slow intravenous injections of 10–25 mg repeated at 3–6 hours until normalisation of the prothrombin time; then 10 mg orally four times daily as a "maintenance dose"). It is an extremely effective antidote, provided the ...
Warning label on a tube of rat poison containing bromadiolone on a dike of the Scheldt river in Steendorp, Belgium. Bromadiolone is a potent anticoagulant rodenticide.It is a second-generation 4-hydroxycoumarin derivative and vitamin K antagonist, often called a "super-warfarin" for its added potency and tendency to accumulate in the liver of the poisoned organism.
The enhancement to the molecule takes the form of a larger lipophilic group to enhance the fat solubility of the poison and greatly increase the time it acts within the animal's body. [5] However, as described above, the superwarfarins do not inhibit vitamin K and their effect is easily inhibited by vitamin K.
Cases of food poisoning began to be reported in the New York State area on October 18, 2012. The CDC eventually concluded this was an example of O157:H7, its code for a strain of E. coli that is noteworthy for seeming to have genes from a different species, shigella, producing an unusual toxin, though not one especially lethal to human beings ...
Brodifacoum takes a very long time to break down in soil and water and accumulates in the tissue of exposed animals for years. Consequently, there is a very high risk of by-kill: it is known to have killed at least 21 species of native birds, including kiwi , kākā , kākāriki and tūī . [ 76 ]
Their latest research estimates that 151 million cases of psychiatric disorders—including depression, anxiety, and hyperactivity— from the past 75 years can be traced to childhood lead exposure.
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The initial 1950's ad pitch emphasized the following points: rats do a large amount of damage to crops each year ("$22 a year per rat"); d-CON poses minimal risk to other animals; the product is undetectable (odorless and tasteless) by rats and does not produce bait shyness; and, the product was successfully tested in Middleton, Wisconsin.