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The primary antidote to brodifacoum poisoning is immediate administration of vitamin K 1 (dosage for humans: initially slow intravenous injections of 10–25 mg repeated at 3–6 hours until normalisation of the prothrombin time; then 10 mg orally four times daily as a "maintenance dose"). It is an extremely effective antidote, provided the ...
Warning label on a tube of rat poison containing bromadiolone on a dike of the Scheldt river in Steendorp, Belgium. Bromadiolone is a potent anticoagulant rodenticide.It is a second-generation 4-hydroxycoumarin derivative and vitamin K antagonist, often called a "super-warfarin" for its added potency and tendency to accumulate in the liver of the poisoned organism.
This led to the introduction of brodifacoum in 1975, followed by d-CON's introduction of it in the commercial market in the 1980s. [13] The compound works similarly to warfarin, but requires fewer doses. Additionally, it causes an unquenchable thirst, causing rats to leave the home in search of water before dying. [14]
The enhancement to the molecule takes the form of a larger lipophilic group to enhance the fat solubility of the poison and greatly increase the time it acts within the animal's body. [5] However, as described above, the superwarfarins do not inhibit vitamin K and their effect is easily inhibited by vitamin K.
Harmful algae blooms produce toxins that can poison humans, ... Nerve toxins, or nerve poisoning can cause people to experience dizziness, tingling in fingers and toes and numbness of lips. A skin ...
[13] [14] In 2018, the United States Food and Drug Administration warned of significant health risks from synthetic cannabinoid products that contain the rat poison brodifacoum, which is added because it is thought to extend the duration of the drugs' effects. [15] Severe illnesses and death have resulted from this contamination. [15]
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Generaly speaking, brodifacoum like all coumarin anticoagulants do cause progressive toxicosis leading to death in a timespan of between 2 and 10 days after the ingestion of a lethal dose. This is similar for every indirect anticoagulant and has to do with the mechanism of action being progressive, rather slow, as described.