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  2. What is gabapentin? Here's why it's so controversial. - AOL

    www.aol.com/gabapentin-heres-why-controversial...

    Gabapentin is a prescription medication that was approved by the U.S. Food and Drug Administration in 1993 as a treatment for epilepsy. It works by binding to a type of calcium channel in nerve ...

  3. Gabapentin - Wikipedia

    en.wikipedia.org/wiki/Gabapentin

    A combination of gabapentin with an opioid or nortriptyline may work better than either drug alone. [11] [33] Gabapentin shows substantial benefit (at least 50% pain relief or a patient global impression of change (PGIC) "very much improved") for neuropathic pain (postherpetic neuralgia or peripheral diabetic neuropathy) in 30–40% of subjects ...

  4. Gabapentinoid - Wikipedia

    en.wikipedia.org/wiki/Gabapentinoid

    The gabapentinoid drugs do not bind significantly to other known drug receptors and so the α 2 δ VGCC subunit has been called the gabapentin receptor. [ 15 ] [ 4 ] Recently, the same α 2 δ-1 protein has been found closely associated not with VGCCs but with other proteins such as presynaptic NMDA-type glutamate receptors , cell adhesion ...

  5. Can Gabapentin Really Cause ED? - AOL

    www.aol.com/lifestyle/gabapentin-really-cause-ed...

    Gabapentin is sometimes used in an off-label capacity, meaning healthcare providers prescribe it for things the FDA (U.S. Food and Drug Administration) hasn’t approved it for.

  6. Gabapentin enacarbil - Wikipedia

    en.wikipedia.org/wiki/Gabapentin_enacarbil

    Gabapentin enacarbil (Horizant (ER) (U.S. Tooltip United States), Regnite (in Japan)) is an anticonvulsant and analgesic drug of the gabapentinoid class, and a prodrug to gabapentin. [1] It was designed for increased oral bioavailability over gabapentin, [ 2 ] [ 3 ] and human trials showed it to produce extended release of gabapentin with ...

  7. Pain management - Wikipedia

    en.wikipedia.org/wiki/Pain_management

    These drugs also reduce pain from viruses such as shingles, phantom limb pain and post-stroke pain. [74] These mechanisms vary and in general are more effective in neuropathic pain disorders as well as complex regional pain syndrome. [75] A common anti-epileptic drug is gabapentin, and an example of an antidepressant would be amitriptyline.

  8. GABA reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/GABA_reuptake_inhibitor

    A GABA reuptake inhibitor (GRI) is a type of drug which acts as a reuptake inhibitor for the neurotransmitter gamma-Aminobutyric acid (GABA) by blocking the action of the gamma-Aminobutyric acid transporters (GATs). This in turn leads to increased extracellular concentrations of GABA and therefore an increase in GABAergic neurotransmission. [1]

  9. Fibromyalgia - Wikipedia

    en.wikipedia.org/wiki/Fibromyalgia

    The anti-convulsant medications gabapentin and pregabalin may be used to reduce pain. [8] There is tentative evidence that gabapentin may be of benefit for pain in about 18% of people with fibromyalgia. [8] It is not possible to predict who will benefit, and a short trial may be recommended to test the effectiveness of this type of medication.

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