Search results
Results from the WOW.Com Content Network
With a diameter of 15–22 μm, monocytes are the largest cell type in peripheral blood. [2] [3] Monocytes are mononuclear cells and the ellipsoidal nucleus is often lobulated/indented, causing a bean-shaped or kidney-shaped appearance. [4] Monocytes compose 2% to 10% of all leukocytes in the human body.
CCR2 surface expression on blood monocytes changes in a time-of-day–dependent manner (being higher at the beginning of the active phase) and affects monocytes recruitment in tissues including the heart. As a consequence when an acute ischemic event happens during the active phase, monocytes are more susceptible to invade the heart. [10]
The mononuclear phagocyte system and the monocyte macrophage system refer to two different entities, often mistakenly understood as one. [citation needed] "Reticuloendothelial system" is an older term for the mononuclear phagocyte system, but it is used less commonly now, as it is understood that most endothelial cells are not macrophages. [2]
A peripheral blood mononuclear cell (PBMC) is any peripheral blood cell having a round nucleus. [1] These cells consist of lymphocytes (T cells, B cells, NK cells) and monocytes, whereas erythrocytes and platelets have no nuclei, and granulocytes (neutrophils, basophils, and eosinophils) have multi-lobed nuclei. In humans, lymphocytes make up ...
The image on the left shows a monocyte actively phagocytizing an antibody-sensitized red blood cell. The image on the right shows multiple RBC that have been phagocytized by a single monocyte. The monocyte monolayer assay (MMA) is used to determine the clinical significance of alloantibodies produced by blood transfusion recipients. [1]
The second chain of α M β 2 is the common integrin β 2 subunit known as CD18, and integrin α M β 2 thus belongs to the β 2 subfamily (or leukocyte) integrins. [ 6 ] α M β 2 is expressed on the surface of many leukocytes involved in the innate immune system , including monocytes , granulocytes , macrophages , and natural killer cells [ 5 ...
Monocytosis is an increase in the number of monocytes circulating in the blood. [1] Monocytes are white blood cells that give rise to macrophages and dendritic cells in the immune system. In humans, monocytosis occurs when there is a sustained rise in monocyte counts greater than 800/mm 3 to 1000/mm 3. [2]
The infiltration of bone-marrow-derived monocytes generated postnatally creates a distinct population of dermal macrophages. They are LY6C hi monocytes, a type of circulating monocyte in the blood. The entry of LY6C hi monocytes to the dermis is CCR2-pathway-dependent. [5] Their subsequent differentiation will create the postnatal population.