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  2. Muscarinic acetylcholine receptor M3 - Wikipedia

    en.wikipedia.org/wiki/Muscarinic_acetylcholine...

    The muscarinic M 3 receptor regulates insulin secretion from the pancreas [7] and are an important target for understanding the mechanisms of type 2 diabetes mellitus.. Some antipsychotic drugs that are prescribed to treat schizophrenia and bipolar disorder (such as olanzapine and clozapine) have a high risk of diabetes side-effects.

  3. Olanzapine - Wikipedia

    en.wikipedia.org/wiki/Olanzapine

    Olanzapine occupancy at 5-HT 2A receptor are high at all doses (5 mg to 20 mg). It is reported that 5 mg dose of olanzapine produced a mean occupancy of 85% at 5 mg, 88% at 10 mg, and 93% at 20 mg dose . [95] Olanzapine had the highest affinity of any second-generation antipsychotic towards the P-glycoprotein in one in vitro study. [96]

  4. Muscarinic acetylcholine receptor - Wikipedia

    en.wikipedia.org/wiki/Muscarinic_acetylcholine...

    The M 3 receptors are also located in many glands, which help to stimulate secretion in, for example, the salivary glands, as well as other glands of the body. Like the M 1 muscarinic receptor, M 3 receptors are G proteins of class G q that upregulate phospholipase C and, therefore, inositol trisphosphate and intracellular calcium as a ...

  5. List of adverse effects of olanzapine - Wikipedia

    en.wikipedia.org/wiki/List_of_adverse_effects_of...

    Weight gain (dose-dependent). Weight gain of over 7% of a person's initial body weight prior to treatment is in this category of very common too with some estimates of its incidence putting it at around 40.6%. This adverse effect is most likely the result of its potent 5-HT 2C receptor and H 1 receptor blockade (or more specifically inverse ...

  6. Muscarinic agonist - Wikipedia

    en.wikipedia.org/wiki/Muscarinic_agonist

    A muscarinic acetylcholine receptor agonist, also simply known as a muscarinic agonist or as a muscarinic agent, is an agent that activates the activity of the muscarinic acetylcholine receptor. [1] The muscarinic receptor has different subtypes, labelled M1-M5, allowing for further differentiation.

  7. Category:M3 receptor antagonists - Wikipedia

    en.wikipedia.org/wiki/Category:M3_receptor...

    This page was last edited on 24 October 2024, at 14:56 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.

  8. Olanzapine/samidorphan - Wikipedia

    en.wikipedia.org/wiki/Olanzapine/samidorphan

    Olanzapine/samidorphan, sold under the brand name Lybalvi, is a fixed-dose combination medication for the treatment of schizophrenia and bipolar I disorder. [1] It contains olanzapine , an atypical antipsychotic , and samidorphan , an opioid antagonist .

  9. Parasympathomimetic drug - Wikipedia

    en.wikipedia.org/wiki/Parasympathomimetic_drug

    A parasympathomimetic drug, sometimes called a cholinomimetic drug [1] or cholinergic receptor stimulating agent, [2] is a substance that stimulates the parasympathetic nervous system (PSNS). [ 3 ] [ 2 ] These chemicals are also called cholinergic drugs because acetylcholine (ACh) is the neurotransmitter used by the PSNS.

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