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The basal ganglia (BG) or basal nuclei are a group of subcortical nuclei found in the brains of vertebrates. In humans and other primates , differences exist, primarily in the division of the globus pallidus into external and internal regions, and in the division of the striatum .
The basal ganglia is a collective group of structures in the brain. These include the striatum, (composed of the putamen and caudate nucleus), globus pallidus, substantia nigra, and the subthalamic nucleus. Along with other structures, the basal ganglia are part of a neural circuit that is integral to voluntary motor function. [1]
The substantia nigra (SN) is a basal ganglia structure located in the midbrain that plays an important role in reward and movement. Substantia nigra is Latin for "black substance", reflecting the fact that parts of the substantia nigra appear darker than neighboring areas due to high levels of neuromelanin in dopaminergic neurons. [1]
Neuroferritinopathy is classified as a late-onset basal ganglia disease and is a dominantly inherited neurodegenerative disease. [3] Four different alleles are responsible for neuroferritinopathy. Three arise from nucleotide insertions in the ferritin light chain (FTL) polypeptide gene while the fourth arises from a missense mutation in the FTL ...
It also involves another basal ganglia component the substantia nigra, a part of the midbrain. [2] In a resting individual, a specific region of the globus pallidus, the internal globus pallidus (GPi), and a part of the substantia nigra, the pars reticulata (SNpr), send spontaneous inhibitory signals to the ventral lateral nucleus (VL) of the ...
The globus pallidus (GP), also known as paleostriatum or dorsal pallidum, [1] is a major component of the subcortical basal ganglia in the brain.It consists of two adjacent segments, one external (or lateral), known in rodents simply as the globus pallidus, and one internal (or medial).
The external capsule is a route for cholinergic fibers from the basal forebrain to the cerebral cortex. The putamen separates the external capsule from the internal capsule medially and the claustrum separates it from the extreme capsule laterally.
The substantia nigra is located in the ventral midbrain of each hemisphere. It has two distinct parts, the pars compacta (SNc) and the pars reticulata (SNr). The pars compacta contains dopaminergic neurons from the A9 cell group that forms the nigrostriatal pathway that, by supplying dopamine to the striatum, relays information to the basal ganglia.