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Low levels of thyroid hormones can lead to symptoms including fatigue, weight gain, cold intolerance, dry, flakey skin, loss of hair and inability to concentrate.
The most common drugs in this class are thioamides, which include propylthiouracil, methimazole and its prodrug carbimazole. Additionally, propylthiouracil may reduce the de-iodination of thyroxine (T 4) into triiodothyronine (T 3) in peripheral tissues. [2] Lugol's iodine is used to temporarily block thyroid hormone synthesis before surgeries. [3]
See Thyroid hormones § Thyroid metabolism for more information on its biosynthesis. [citation needed] Industrially, levothyroxine is made by chemical synthesis. Tyrosine is a common starting material. [36] The produced hormone is incorporated into drugs as its sodium salt, levothyroxine sodium.
[1] [2] Some thyromimetic drugs are selective for various of these receptors over others, enabling more targeted effects and reducing toxicity. Thyromimetics selective for TRβ—including eprotirome , [ 3 ] sobetirome , [ 4 ] resmetirom , [ 5 ] and the prodrug VK2809 —have been investigated for the treatment of non-alcoholic fatty liver ...
Propylthiouracil (PTU) is a medication used to treat hyperthyroidism. [3] This includes hyperthyroidism due to Graves' disease and toxic multinodular goiter. [3] In a thyrotoxic crisis it is generally more effective than methimazole. [3] Otherwise it is typically only used when methimazole, surgery, and radioactive iodine is not possible. [3]
Thyroid tumors, thyroid cancer, and vision changes are also potential side effects of Ozempic, per Novo Nordisk. There is also a risk of eating disorders when taking Ozempic, says Dr. Kumar ...
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