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Leptospirosis is a blood infection caused by the bacteria Leptospira [8] that can infect humans, dogs, rodents and many other wild and domesticated animals. [8] Signs and symptoms can range from none to mild ( headaches , muscle pains , and fevers ) to severe ( bleeding in the lungs or meningitis ). [ 5 ]
Treatment should begin with assessment and management of the bite wound. The wound should be well irrigated. Although rats and small rodents are rarely infected with rabies, the individual must seek medical attention for possible tetanus or rabies post-exposure prophylaxis. Antibiotic therapy should be started immediately as laboratory ...
Doxycycline is a broad-spectrum antibiotic of the tetracycline class used in the treatment of infections caused by bacteria and certain parasites. [1] It is used to treat bacterial pneumonia , acne , chlamydia infections , Lyme disease , cholera , typhus , and syphilis . [ 1 ]
Doxycycline is also used as a prophylactic treatment for infection by Bacillus anthracis and is effective against Yersinia pestis, the infectious agent of bubonic plague. It is also used for malaria treatment and prophylaxis, as well as treating elephantitis filariasis. [10]
The CDC issued its draft proposal as the rate of sexually transmitted infections rises across the United States with more than 2.5 million cases reported in 2021, a jump of 7% in one year ...
Leptospirosis in canines can be divided into the four categories of reproductive, icteric, hemorrhagic, and uremic. Reproductive leptospirosis results in the premature birth of offspring or abortion, and uremic leptospirosis is referred to as Stuttgart disease. [32] L. interrogans triggers a highly inflammatory response in infected dogs.
First diagnosis of aHUS is often made in the context of an initial, complement-triggering infection, and Shiga-toxin has also been implicated as a trigger that identifies patients with aHUS. Treatment involves supportive care and may include dialysis , steroids , blood transfusions , and plasmapheresis .
Also, the virulence factors on the flagella of pathogenic leptospires have thought to be involved in the overall infection. [15] Leptospira noguchii specifically creates a median lethal dose (LD 50) of three to 100 leptospires. [15] L. noguchii also uses the Lsa24 protein to avoid the immune system of the host and antibacterials by binding to ...
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