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Doxylamine and other first-generation antihistamines are the most widely used sleep medications in the world. [6] Typical side effects of doxylamine (at recommended doses) include dizziness, drowsiness, grogginess, and dry mouth, among others. [7] [4] As an antihistamine, doxylamine is an inverse agonist of the histamine H 1 receptor.
Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine hydrochloride (vitamin B 6) and doxylamine succinate.It is generally used for nausea and vomiting of pregnancy (morning sickness); even though its efficacy has not been proven and subsequent research has led to the removal of recommendations in medical journals.
Doses of hydroxyzine hydrochloride used for sleep range from 25 to 100 mg. [15] [16] [17] As with other antihistamine sleep aids, hydroxyzine is usually only prescribed for short term or "as-needed" use since tolerance to the CNS (central nervous system) effects of hydroxyzine can develop in as little as a few days.
It is mainly used to treat allergies, insomnia, and symptoms of the common cold. It is also less commonly used for tremors in parkinsonism, and nausea. [11] It is taken by mouth, injected into a vein, injected into a muscle, or applied to the skin. [11] Maximal effect is typically around two hours after a dose, and effects can last for up to ...
There is no good evidence that melatonin helps treat insomnia and its attempted use for this purpose is recommended against by the American Academy of Sleep Medicine. [28] A prolonged-release form of melatonin is approved for use as a medication in Europe for the treatment of insomnia in certain people. [11] [29]
The withdrawal and rebound insomnia that is typical with GABA A receptor positive modulators like benzodiazepines and Z-drugs is not present in ramelteon. [3] Increased incidence of liver and testicular tumors have been observed with ramelteon in rodents but only at doses equivalent to at least 20 times greater than the recommended dose in ...
The claim: California counting ballots two weeks after Election Day is evidence it was ‘rigged’ A Nov. 19 Instagram post (direct link, archive link) claims one state’s lengthy vote-counting ...
Zolpidem, sold under the brand name Ambien among others, is a medication primarily used for the short-term treatment of sleeping problems. [11] [16] Guidelines recommend that it be used only after cognitive behavioral therapy for insomnia and after behavioral changes, such as sleep hygiene, have been tried.
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