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  2. Spironolactone - Wikipedia

    en.wikipedia.org/wiki/Spironolactone

    Some of these uses include acne, seborrhea, hirsutism, and pattern hair loss in women. [38] Spironolactone is used for the treatment of hirsutism in the United States. [39] High doses of spironolactone, which are needed for considerable antiandrogenic effects, are not recommended for men due to the high risk of feminization and other side effects.

  3. Pharmacodynamics of spironolactone - Wikipedia

    en.wikipedia.org/wiki/Pharmacodynamics_of...

    Androgen receptor antagonistic potency of spironolactone, cyproterone acetate, and flutamide in castrated male rats treated with exogenous testosterone (as measured by inhibition of androgen-dependent ventral prostate weight). [27] Spironolactone is an antagonist of the AR, the biological target of androgens like testosterone and DHT.

  4. Anti-obesity medication - Wikipedia

    en.wikipedia.org/wiki/Anti-obesity_medication

    Weight loss drugs have been developed since the early twentieth century, and many have been banned or withdrawn from the market due to adverse effects, including deaths; other drugs proved ineffective. Although many earlier drugs were stimulants such as amphetamines, in the early 2020s, GLP-1 receptor agonists became popular for weight loss.

  5. Comparison of bicalutamide with other antiandrogens

    en.wikipedia.org/wiki/Comparison_of_bicalutamide...

    Unlike spironolactone, bicalutamide has no antimineralocorticoid activity, [97] and for this reason, has no risk of hyperkalemia (which can, rarely/in severe cases, result in hospitalization or death) [112] or other antimineralocorticoid side effects such as urinary frequency, dehydration, hypotension, hyponatremia, metabolic acidosis, or ...

  6. 7α-Thiospironolactone - Wikipedia

    en.wikipedia.org/wiki/7α-thiospironolactone

    Spironolactone is a prodrug with a short terminal half-life of 1.4 hours. [5] [6] [7] The active metabolites of spironolactone have extended terminal half-lives of 13.8 hours for 7α-TMS, 15.0 hours for 6β-OH-7α-TMS, and 16.5 hours for canrenone, and accordingly, these metabolites are responsible for the therapeutic effects of the drug. [5] [6]

  7. Can Weight Loss Drugs Make You Boring? Doctors Explain ...

    www.aol.com/lifestyle/weight-loss-drugs-boring...

    GLP-1 users have also reported a decreased libido, irritability, and being quieter or more monotone, according to experiences shared on a Reddit post. “I feel more subdued and almost like I lost ...

  8. Drospirenone - Wikipedia

    en.wikipedia.org/wiki/Drospirenone

    [9] [3] The medication is an analog of the drug spironolactone. [10] Drospirenone is taken by mouth. [1] [3] Common side effects include acne, headache, breast tenderness, weight increase, and menstrual changes. [3] Rare side effects may include high potassium levels and blood clots (when taken as a combined oestrogen-progestogen pill), among ...

  9. Eplerenone - Wikipedia

    en.wikipedia.org/wiki/Eplerenone

    Eplerenone may have a lower incidence than spironolactone of sexual side effects such as feminization, gynecomastia, impotence, low sex drive and reduction of size of male genitalia. [18] This is because other antimineralocorticoids have structural elements of the progesterone molecule, causing progestogenic and antiandrogenic outcomes. [ 4 ]

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