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Carboplatin, sold under the brand name Paraplatin among others, is a chemotherapy medication used to treat a number of forms of cancer. [3] This includes ovarian cancer, lung cancer, head and neck cancer, brain cancer, and neuroblastoma. [3] It is used by injection into a vein. [3] Side effects generally occur. [3]
Combined use of Cisplatin and Etoposide has become the first-line chemotherapy for limited-stage small cell lung cancer since 1980s. [22] Carboplatin can also be used as a substitute when patient is intolerant of cisplatin. [23]
Side effects are very common. [2] They can include low blood cell counts, vomiting, loss of appetite, diarrhea, hair loss, and fever. [2] Other severe side effects include allergic reactions and low blood pressure. [2] [4] Use during pregnancy will likely harm the fetus. [2] Etoposide is in the topoisomerase inhibitor family of medication. [2]
In this form of chemotherapy, commonly used drugs include cisplatin, oxaliplatin, and carboplatin, but several have been proposed or are under development. [1] Addition of platinum-based chemotherapy drugs to chemoradiation in women with early cervical cancer seems to improve survival and reduce risk of recurrence.
Some of the substances require conversion into active substances in vivo (e.g., cyclophosphamide).. Cyclophosphamide is one of the most potent immunosuppressive substances. In small dosages, it is very efficient in the therapy of systemic lupus erythematosus, autoimmune hemolytic anemia, granulomatosis with polyangiitis, and other autoimmune diseases.
A chemotherapy regimen is a regimen for chemotherapy, defining the drugs to be used, their dosage, the frequency and duration of treatments, and other considerations.In modern oncology, many regimens combine several chemotherapy drugs in combination chemotherapy.
Etoposide is a highly schedule-dependent drug and is typically administered orally and recommended to take twice the dosage for effective treatment. [13] [68] However, with the selective dosage, etoposide treatment is dose limiting proposing toxic effects like myelosupression (leukopenia) and primarily hematologic.
Cisplatin is administered intravenously as short-term infusion in normal saline for treatment of solid and haematological malignancies. It is used to treat various types of cancers, including sarcomas, some carcinomas (e.g., small cell lung cancer, squamous cell carcinoma of the head and neck and ovarian cancer), lymphomas, bladder cancer, cervical cancer, [9] and germ cell tumors.
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