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The FDA approved lasmiditan primarily based on data from two clinical trials, Trial 1 (# NCT02439320) and Trial 2 (#NCT02605174) of 4439 subjects with migraine headaches with or without aura. [19] Trials were conducted at 224 sites in the United States, the United Kingdom, and Germany. [19] The FDA approved the drug in October 2019. [19]
Zavzpret is a new nasal spray to treat migraine headaches in adults. But how does the medication work and who should try the new FDA-approved medication?
Zavegepant, sold under the brand name Zavzpret, is a medication used for the treatment of migraine. [1] Zavegepant is a calcitonin gene-related peptide receptor antagonist. [1] It is sprayed into the nose. [1] It is sold by Pfizer. [1] The most common adverse reactions include taste disorders, nausea, nasal discomfort, and vomiting. [1]
Rimegepant, sold under the brand name Nurtec ODT among others, is a medication used for the acute treatment of migraine with or without aura in adults and the prophylactic/ preventive treatment of episodic migraine in adults. [8] [10] It is taken by mouth to dissolve on or under the tongue. [8] It works by blocking CGRP receptors. [11]
The U.S. Food and Drug Administration has approved Pfizer's newest drug on the migraine market, Zavzpret (zavegepant) -- the first and only migraine treatment of its kind to be offered in nasal spray.
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