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Certain underlying health conditions can increase the risk of gout as well: Kidney disease. Obesity. Diabetes. High blood pressure. Heart disease. Taking certain types of medications can ...
In general, this effect is achieved by action on the proximal tubule of the kidney. Drugs that reduce blood uric acid are not all uricosurics; blood uric acid can be reduced by other mechanisms (see other Antigout Medications). Uricosurics are often used in the treatment of gout, a disease in which uric acid crystals form deposits in the joints.
An individual can have serum values as high as 96 mg/L and not have gout. [18] In humans, about 70% of daily uric acid disposal occurs via the kidneys, and in 5–25% of humans, impaired renal (kidney) excretion leads to hyperuricemia. [19]
Unless high blood levels of uric acid are determined in a clinical laboratory, hyperuricemia may not cause noticeable symptoms in most people. [5] Development of gout – which is a painful, short-term disorder – is the most common consequence of hyperuricemia, which causes deposition of uric acid crystals usually in joints of the extremities, but may also induce formation of kidney stones ...
Gout most often affects middle-aged and older men. In fact, men are three to 10 times more likely to have gout than women. However, younger men and women of all ages can have gout.
It may also result in tophi, kidney stones, or urate nephropathy. [3] Cause 1 ... Gout affects about 1 to 2% of the Western population at some point in their lives. [3]
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