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The term seizure threshold is used to describe the balance between excitatory (glutaminergic) and inhibitory (GABA-ergic) forces in the brain which affect how susceptible a person is to seizures. Those diagnosed with epilepsy or certain other neurological conditions are more vulnerable to seizures if the threshold is reduced, and should be ...
Dogs that die of Benadryl overdose go into seizures and then experience respiratory failure, and their heart slows down (2). ... so the toxic dose may be a lot lower, and if your dog has a health ...
Methade, or 6-(dimethylamino)-4,4-diphenylheptane, is the parent compound of the methadone and methadol series of opioid analgesics: [1]. Derived from the chemical structure of methadone, various analogs and derivatives have been synthesized and developed to enhance its therapeutic properties and minimize potential side effects.
Opioid-induced hyperalgesia (OIH) or opioid-induced abnormal pain sensitivity, also called paradoxical hyperalgesia, is an uncommon condition of generalized pain caused by the long-term use of high dosages of opioids [1] such as morphine, [2] oxycodone, [3] and methadone.
Methadone has been shown to reduce neuropathic pain in rat models, primarily through NMDA receptor antagonism. [ citation needed ] NMDA antagonists such as dextromethorphan , ketamine , tiletamine and ibogaine are being studied for their role in decreasing the development of tolerance to opioids and as possible for eliminating addiction ...
A bottle of veterinary pharmaceutical potassium bromide oral solution used in dogs, primarily as an antiepileptic (to stop seizures) [3] In dogs, epilepsy is often an inherited condition. The incidence of epilepsy/seizures in the general dog population is estimated to be between 0.5% and 5.7%. [4]
Opioid agonist therapy (OAT) is a treatment in which prescribed opioid agonists are given to patients who live with Opioid use disorder (OUD). [1] In the case of methadone maintenance treatment (MMT), methadone is used to treat dependence on heroin or other opioids, and is administered on an ongoing basis.
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]