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3-Indolepropionic acid (IPA), or indole-3-propionic acid, has been studied for its therapeutic value in the treatment of Alzheimer's disease. As of 2022 [ 3 ] IPA shows potential in the treatment of this disease, though the therapeutic effect of IPA depends on dose and time of therapy initiation.
Clostridium sporogenes metabolizes tryptophan into indole and subsequently 3-indolepropionic acid (IPA), [5] a highly potent neuroprotective antioxidant that scavenges hydroxyl radicals. [2] [6] [7] IPA binds to the pregnane X receptor (PXR) in intestinal cells, thereby facilitating mucosal homeostasis and barrier function. [2]
Clostridium sporogenes metabolizes tryptophan into indole and subsequently 3-indolepropionic acid (IPA), [2] a highly potent neuroprotective antioxidant that scavenges hydroxyl radicals. [1] [3] [4] IPA binds to the pregnane X receptor (PXR) in intestinal cells, thereby facilitating mucosal homeostasis and barrier function. [1]
Clostridium sporogenes colonizes the human gastrointestinal tract, but is only present in a subset of the population; in the intestine, it uses tryptophan to synthesize indole and subsequently 3-indolepropionic acid (IPA) [5] – a type of auxin (plant hormone) [6] [7] – which serves as a potent neuroprotective antioxidant within the human ...
3-Indolepropionic acid (IPA), or indole-3-propionic acid; Phensuximide This page was last edited on 1 March 2021, at 22:13 (UTC). Text is available under the ...
Clostridium sporogenes metabolizes tryptophan into indole and subsequently 3-indolepropionic acid (IPA), [13] a highly potent neuroprotective antioxidant that scavenges hydroxyl radicals. [12] [14] [15] IPA binds to the pregnane X receptor (PXR) in intestinal cells, thereby facilitating mucosal homeostasis and barrier function. [12]
Clostridium sporogenes metabolizes tryptophan into indole and subsequently 3-indolepropionic acid (IPA), [21] a highly potent neuroprotective antioxidant that scavenges hydroxyl radicals. [20] [22] [23] IPA binds to the pregnane X receptor (PXR) in intestinal cells, thereby facilitating mucosal homeostasis and barrier function. [20]
Clostridium sporogenes metabolizes tryptophan into indole and subsequently 3-indolepropionic acid (IPA), [67] a highly potent neuroprotective antioxidant that scavenges hydroxyl radicals. [66] [68] [69] IPA binds to the pregnane X receptor (PXR) in intestinal cells, thereby facilitating mucosal homeostasis and barrier function. [66]
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