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Syphilis (/ ˈ s ɪ f ə l ɪ s /) is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. [1] The signs and symptoms depend on the stage it presents: primary, secondary, latent or tertiary.
The first effective treatment for a sexually transmitted infection was salvarsan, a treatment for syphilis. With the discovery of antibiotics , a large number of sexually transmitted infections became easily curable, and this, combined with effective public health campaigns against STIs, led to a public perception during the 1960s and 1970s ...
A new proven protocol in which doxycycline is used to prevent sexually transmitted infections — called doxyPEP — has been an apparent sleeper hit among gay and bisexual men.
Treponema pallidum, formerly known as Spirochaeta pallida, is a microaerophilic, gram-negative, spirochaete bacterium with subspecies that cause the diseases syphilis, bejel (also known as endemic syphilis), and yaws. [1] It is known to be transmitted only among humans and baboons. [2]
All patients with syphilis should be tested for HIV infection. [15] All cases of syphilis should be reported to public health authorities and public health departments can aid in partner notification, testing, and determining need for treatment. [16] The treatment success is measured with a fourfold drop in the nontreponemal antibody test.
Syphilis is a bacterial infection transmitted by sexual contact [2] and is believed to have infected 12 million people in 1999 with greater than 90% of cases in the developing world. [3] It affects between 700,000 and 1.6 million pregnancies a year, resulting in spontaneous abortions , stillbirths , and congenital syphilis . [ 4 ]
Intravenous penicillin has been the primary treatment for syphilitic aortitis since the 1940s. The underlying bacterium of syphilis, T. pallidum, continues to be sensitive to penicillin as the lack of horizontal gene transfer mechanisms makes it difficult for the bacterium to mutate and resist treatment. [4]
The history of syphilis has been well studied, but the exact origin of the disease remains unknown. [3] It appears to have originated in both Africa and America. [4] [5] As such, there are two primary hypotheses: one proposes that syphilis was carried to Europe from the Americas by the crew(s) of Christopher Columbus as a byproduct of the Columbian exchange, while the other proposes that ...
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