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Leflunomide, sold under the brand name Arava among others, is an immunosuppressive disease-modifying antirheumatic drug , [8] used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase. [9] Bottle of Leflunomide (Arava) and tablet
csDMARDs are the traditional drugs (such as methotrexate, sulfasalazine, leflunomide, hydroxychloroquine, gold salts) tsDMARDs are drugs that were developed to target a particular molecular structure; biological (bDMARD) can be further separated into original and biosimilar DMARDs (boDMARDs and bsDMARDs)
This is considered a simple structural modification and a technically simple one-step synthetic transformation. Upon oral administration of leflunomide in vivo, the isoxazole ring of leflunomide is opened and teriflunomide is formed. [15] Teriflunomide is the only active metabolite of leflunomide, completely responsible for its therapeutic actions.
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Leflunomide has been shown to bind in this tunnel. [7] Leflunomide is being used for treatment of rheumatoid and psoriatic arthritis , as well as multiple sclerosis . [ 2 ] [ 7 ] Its immunosuppressive effects have been attributed to the depletion of the pyrimidine supply for T cells or to more complex interferon or interleukin -mediated ...
This multi-page article lists pharmaceutical drugs alphabetically by name. Many drugs have more than one name and, therefore, the same drug may be listed more than once. ...
Arava, a brand name for the antirheumatic drug leflunomide Arava Shahaf (born 1990), Israeli female footballer Aravah (Sukkot) , a willow branch, one of the four species used on the Jewish holiday of Sukkot
There are no dosing guidelines for leflunomide in BKVAN. Patient to patient variability has made dosing and monitoring of leflunomide extremely difficult. Study of 26 and 17 patients were dosed between 20 mg/day and 60 mg/day with trough levels of 50—100 μg/ml. Failure was seen in patients with leflunomide plasma levels < 40 μg/ml ...