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Leflunomide, sold under the brand name Arava among others, is an immunosuppressive disease-modifying antirheumatic drug , [8] used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase. [9] Bottle of Leflunomide (Arava) and tablet
This is considered a simple structural modification and a technically simple one-step synthetic transformation. Upon oral administration of leflunomide in vivo, the isoxazole ring of leflunomide is opened and teriflunomide is formed. [15] Teriflunomide is the only active metabolite of leflunomide, completely responsible for its therapeutic actions.
csDMARDs are the traditional drugs (such as methotrexate, sulfasalazine, leflunomide, hydroxychloroquine, gold salts) tsDMARDs are drugs that were developed to target a particular molecular structure; biological (bDMARD) can be further separated into original and biosimilar DMARDs (boDMARDs and bsDMARDs)
Arava or Aravah is the Hebrew name of a section of the Great Rift Valley between the Dead Sea and the Gulf of Aqaba/Eilat in Israel and Jordan. Its Arabic name is Arabah. Its Arabic name is Arabah. Arava may also refer to:
The most commonly used agent is methotrexate with other frequently used agents including sulfasalazine and leflunomide. [8] Leflunomide is effective when used from 6–12 months, with similar effectiveness to methotrexate when used for 2 years. [119] Sulfasalazine also appears to be most effective in the short-term treatment of rheumatoid ...
This multi-page article lists pharmaceutical drugs alphabetically by name. Many drugs have more than one name and, therefore, the same drug may be listed more than once. ...
It is also used in the "wash out" procedure in patients taking leflunomide or teriflunomide to aid drug elimination in the case of drug discontinuation due to severe side effects caused by leflunomide or teriflunomide. [10] A case report suggests that colestyramine may be useful for cyanobacterial (microcystin) poisoning in dogs. [11]
Immunoglobulin therapy is the use of a mixture of antibodies (normal human immunoglobulin) to treat several health conditions. [13] [14] These conditions include primary immunodeficiency, immune thrombocytopenic purpura, chronic inflammatory demyelinating polyneuropathy, Kawasaki disease, certain cases of HIV/AIDS and measles, Guillain–Barré syndrome, and certain other infections when a ...
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